Omega-3 and omega-6 fatty acid exposure from early life does not affect atopy and asthma at age 5 years

Catarina Almqvist, Frances Garden, Wei Xuan, Seema Mihrshahi, Steve R. Leeder, Wendy Oddy, Karen Webb, Guy B. Marks, Childhood Asthma Prevention Study (CAPS) Team

Research output: Contribution to journalArticlepeer-review

105 Citations (Scopus)

Abstract

Background: The Childhood Asthma Prevention Study was a randomized controlled trial conducted in children with a family history of asthma in whom omega-3 fatty acid supplementation and restriction of dietary omega-6 fatty acids did not prevent asthma, eczema, or atopy at age 5 years.

Objective: We sought to examine the relation of all measures of omega-3 and omega-6 polyunsaturated fatty acids with outcomes at age 5 years in the whole birth cohort, regardless of randomization group.

Methods: Plasma fatty acids were measured at 18 months, 3 years, and 5 years. Compliance with the fatty acid supplements was estimated every 6 months. Dietary intake was assessed at 18 months by means of weighed-food record and at 3 years by means of food-frequency questionnaire. At age 5 years, 516 children were examined for wheeze and eczema (questionnaire) and atopy (skin prick tests, n = 488). Multiple logistic regression was used to evaluate associations between exposures and outcomes.

Results: Plasma levels of omega-3 or omega-6 fatty acids were not associated with wheeze, eczema, or atopy at age 5 years (P = .11-.96). Overall, fatty acid exposure, measured as plasma levels, dietary intake, and compliance with supplements, was not associated with any respiratory or allergic outcomes (P = .35-.59).

Conclusion: This observational analysis of the cohort, using the full range of observed variation in omega-3 and omega-6 fatty acid exposure, supports the negative findings of the randomized controlled trial.

Clinical implications: Modification of dietary polyunsaturated fatty acids in early childhood is not helpful in preventing atopy and asthma.
Original languageEnglish
Pages (from-to)1438-1444
Number of pages7
JournalThe Journal of Allergy and Clinical Immunology
Volume119
Issue number6
DOIs
Publication statusPublished - Jun 2007
Externally publishedYes

Keywords

  • asthma
  • allergy and immunology
  • birth cohort
  • child
  • eczema
  • omega-3 fatty acids
  • omega-6 fatty acids
  • primary prevention

Fingerprint

Dive into the research topics of 'Omega-3 and omega-6 fatty acid exposure from early life does not affect atopy and asthma at age 5 years'. Together they form a unique fingerprint.

Cite this