Omega-3 polyunsaturated fatty acids and hyperlipidaemias

J. J. A. Ferguson, C. B. Dias, M. L. Garg*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Citations (Scopus)


Hyperlipidaemia is a multifaceted risk factor for cardiovascular disease, involving multiple aetiologies such as diet, lifestyle, and/or metabolic effects within the body. Dietary long-chain omega-3 polyunsaturated fatty acids (n-3PUFA) have been shown to regulate key pathways involved in lipid metabolism. By this action, n-3PUFA favourably modulate blood lipids such as triglycerides (TG), low-density lipoproteins (LDL), and high-density lipoproteins (HDL). The hypolipidaemic effects of dietary supplementation with n-3PUFA may be enhanced by combination drug or natural therapies and have the potential to reduce dependence on lipid-lowering drug therapy. The widespread modulatory effects on blood lipid profile are not only dose dependent, but also dependent on genetic make-up and gender differences. Further investigation into the modulatory effects of dietary n-3PUFA on blood lipids is warranted in order to optimize the efficacy of n-3PUFA therapy for the prevention and management of hyperlipidaemias. Future studies should investigate the influence of gender and genotypic variants on the effects of dietary n-3PUFA in order to optimize dietary strategies and recommendations to prevent and manage hyperlipidaemias.

Original languageEnglish
Title of host publicationOmega-3 fatty acids
Subtitle of host publicationkeys to nutritional health
EditorsMahabaleshwar V. Hegde, Anand Arvind Zanwar, Sharad P. Adekar
Place of PublicationSwitzerland
PublisherSpringer, Springer Nature
Number of pages12
ISBN (Electronic)9783319404585
ISBN (Print)9783319404561
Publication statusPublished - 1 Jan 2016
Externally publishedYes


  • Docosahexaenoic acid
  • Eicosapentaenoic acid
  • High-density lipoprotein
  • Hyperlipidaemia
  • Lipids
  • Low-density lipoprotein
  • Omega-3 polyunsaturated fatty acids
  • Total cholesterol
  • Triglycerides
  • Very low-density lipoprotein
  • α-linolenic acid


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