Omega-3 polyunsaturated fatty acids and hyperlipidaemias

J. J. A. Ferguson, C. B. Dias, M. L. Garg*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Hyperlipidaemia is a multifaceted risk factor for cardiovascular disease, involving multiple aetiologies such as diet, lifestyle, and/or metabolic effects within the body. Dietary long-chain omega-3 polyunsaturated fatty acids (n-3PUFA) have been shown to regulate key pathways involved in lipid metabolism. By this action, n-3PUFA favourably modulate blood lipids such as triglycerides (TG), low-density lipoproteins (LDL), and high-density lipoproteins (HDL). The hypolipidaemic effects of dietary supplementation with n-3PUFA may be enhanced by combination drug or natural therapies and have the potential to reduce dependence on lipid-lowering drug therapy. The widespread modulatory effects on blood lipid profile are not only dose dependent, but also dependent on genetic make-up and gender differences. Further investigation into the modulatory effects of dietary n-3PUFA on blood lipids is warranted in order to optimize the efficacy of n-3PUFA therapy for the prevention and management of hyperlipidaemias. Future studies should investigate the influence of gender and genotypic variants on the effects of dietary n-3PUFA in order to optimize dietary strategies and recommendations to prevent and manage hyperlipidaemias.

Original languageEnglish
Title of host publicationOmega-3 fatty acids
Subtitle of host publicationkeys to nutritional health
EditorsMahabaleshwar V. Hegde, Anand Arvind Zanwar, Sharad P. Adekar
Place of PublicationSwitzerland
PublisherSpringer, Springer Nature
Chapter6
Pages67-78
Number of pages12
ISBN (Electronic)9783319404585
ISBN (Print)9783319404561
DOIs
Publication statusPublished - 1 Jan 2016
Externally publishedYes

Keywords

  • Docosahexaenoic acid
  • Eicosapentaenoic acid
  • High-density lipoprotein
  • Hyperlipidaemia
  • Lipids
  • Low-density lipoprotein
  • Omega-3 polyunsaturated fatty acids
  • Total cholesterol
  • Triglycerides
  • Very low-density lipoprotein
  • α-linolenic acid

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