Omega-3 polyunsaturated fatty acids and hyperlipidaemias

J. J. A. Ferguson; C. B. Dias; M. L. Garg

doi:10.1007/978-3-319-40458-5_6

Omega-3 polyunsaturated fatty acids and hyperlipidaemias

J. J. A. Ferguson, C. B. Dias, M. L. Garg^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Hyperlipidaemia is a multifaceted risk factor for cardiovascular disease, involving multiple aetiologies such as diet, lifestyle, and/or metabolic effects within the body. Dietary long-chain omega-3 polyunsaturated fatty acids (n-3PUFA) have been shown to regulate key pathways involved in lipid metabolism. By this action, n-3PUFA favourably modulate blood lipids such as triglycerides (TG), low-density lipoproteins (LDL), and high-density lipoproteins (HDL). The hypolipidaemic effects of dietary supplementation with n-3PUFA may be enhanced by combination drug or natural therapies and have the potential to reduce dependence on lipid-lowering drug therapy. The widespread modulatory effects on blood lipid profile are not only dose dependent, but also dependent on genetic make-up and gender differences. Further investigation into the modulatory effects of dietary n-3PUFA on blood lipids is warranted in order to optimize the efficacy of n-3PUFA therapy for the prevention and management of hyperlipidaemias. Future studies should investigate the influence of gender and genotypic variants on the effects of dietary n-3PUFA in order to optimize dietary strategies and recommendations to prevent and manage hyperlipidaemias.

Original language	English
Title of host publication	Omega-3 fatty acids
Subtitle of host publication	keys to nutritional health
Editors	Mahabaleshwar V. Hegde, Anand Arvind Zanwar, Sharad P. Adekar
Place of Publication	Switzerland
Publisher	Springer, Springer Nature
Chapter	6
Pages	67-78
Number of pages	12
ISBN (Electronic)	9783319404585
ISBN (Print)	9783319404561
DOIs	https://doi.org/10.1007/978-3-319-40458-5_6
Publication status	Published - 1 Jan 2016
Externally published	Yes

Keywords

Docosahexaenoic acid
Eicosapentaenoic acid
High-density lipoprotein
Hyperlipidaemia
Lipids
Low-density lipoprotein
Omega-3 polyunsaturated fatty acids
Total cholesterol
Triglycerides
Very low-density lipoprotein
α-linolenic acid

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10.1007/978-3-319-40458-5_6

Link to publication in Scopus

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abstract = "Hyperlipidaemia is a multifaceted risk factor for cardiovascular disease, involving multiple aetiologies such as diet, lifestyle, and/or metabolic effects within the body. Dietary long-chain omega-3 polyunsaturated fatty acids (n-3PUFA) have been shown to regulate key pathways involved in lipid metabolism. By this action, n-3PUFA favourably modulate blood lipids such as triglycerides (TG), low-density lipoproteins (LDL), and high-density lipoproteins (HDL). The hypolipidaemic effects of dietary supplementation with n-3PUFA may be enhanced by combination drug or natural therapies and have the potential to reduce dependence on lipid-lowering drug therapy. The widespread modulatory effects on blood lipid profile are not only dose dependent, but also dependent on genetic make-up and gender differences. Further investigation into the modulatory effects of dietary n-3PUFA on blood lipids is warranted in order to optimize the efficacy of n-3PUFA therapy for the prevention and management of hyperlipidaemias. Future studies should investigate the influence of gender and genotypic variants on the effects of dietary n-3PUFA in order to optimize dietary strategies and recommendations to prevent and manage hyperlipidaemias.",

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