On-line grasp control is mediated by the contralateral hemisphere

Nichola J. Rice, Eugene Tunik, Emily S. Cross, Scott T. Grafton*

*Corresponding author for this work

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Electrophysiological recordings from monkeys, as well as functional imaging and neuropsychological work with humans, have suggested that a region in the anterior portion of the intraparietal sulcus (aIPS) is involved in prehensile movements. With recent methodological advances using transcranial magnetic stimulation (TMS), we can now causally attribute anatomy with function to more precisely determine the specific involvement of aIPS in grasping. It has recently been demonstrated that aIPS is specifically involved in executing a grasp under conditions of both constant target requirements, as well as in correcting a movement under conditions in which a target perturbation occurs. In the present study, we extend these findings by determining the differential contribution of the left and right hemisphere to executing a grasping movement with the left and right hands. Transient disruption of left aIPS at movement onset impairs grasping with the right but not the left hand, and disruption of right aIPS impairs grasping with the left but not the right hand. We conclude that grasping is a lateralized process, relying exclusively on the contralateral hemisphere, and discuss the implications of these findings in relationship to models of hemispheric dominance for motor control.

Original languageEnglish
Pages (from-to)76-84
Number of pages9
JournalBrain Research
Volume1175
DOIs
Publication statusPublished - 17 Oct 2007
Externally publishedYes

Keywords

  • transcranial magnetic stimulation
  • TMS
  • motor control
  • intraparietal sulcus
  • lateralization

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