Oncoproteomics

current status and future opportunities

Yujia He, Abidali Mohamedali, Canhua Huang, Mark S. Baker*, Edouard C. Nice

*Corresponding author for this work

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Oncoproteomics is the systematic study of cancer samples using omics technologies to detect changes implicated in tumorigenesis. Recent progress in oncoproteomics is already opening new avenues for the identification of novel biomarkers for early clinical stage cancer detection, targeted molecular therapies, disease monitoring, and drug development. Such information will lead to new understandings of cancer biology and impact dramatically on the future care of cancer patients.

In this review, we will summarize the advantages and limitations of the key technologies used in (onco)proteogenomics, (the Omics Pipeline), explain how they can assist us in understanding the biology behind the overarching “Hallmarks of Cancer”, discuss how they can advance the development of precision/personalised medicine and the future directions in the field.
Original languageEnglish
Pages (from-to)611-624
Number of pages14
JournalClinica Chimica Acta
Volume495
Early online date6 Jun 2019
DOIs
Publication statusPublished - Aug 2019

Keywords

  • Oncoproteomics
  • Mass spectrometry
  • The hallmarks of cancer
  • The omics pipeline
  • Personalised/precision medicine

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