One-step synthesis of tr̈ger's base hybrids containing at least one halogen atom

Masoud Faroughi; Kai Xian Zhu; Paul Jensen; Donald C. Craig; Andrew C. Try

doi:10.1002/ejoc.200900121

One-step synthesis of tr̈ger's base hybrids containing at least one halogen atom

Masoud Faroughi, Kai Xian Zhu, Paul Jensen, Donald C. Craig, Andrew C. Try

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

The one-step synthesis of a series of hybrid dibenzo Tr̈ger's base analogues bearing at least one halogen atom is described. The strategy involves a reaction between two different anilines and affords hybrid compounds in yields as high as 46%, together with the symmetric Tr̈ger's base products. This straightforward approach requires only one chromatographic step and has the potential to replace multi-step approaches to hybrid Tr̈ger's base compounds.

Original language	English
Pages (from-to)	4266-4272
Number of pages	7
Journal	European Journal of Organic Chemistry
Issue number	25
DOIs	https://doi.org/10.1002/ejoc.200900121
Publication status	Published - Sept 2009

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abstract = "The one-step synthesis of a series of hybrid dibenzo T{\"r}ger's base analogues bearing at least one halogen atom is described. The strategy involves a reaction between two different anilines and affords hybrid compounds in yields as high as 46%, together with the symmetric T{\"r}ger's base products. This straightforward approach requires only one chromatographic step and has the potential to replace multi-step approaches to hybrid T{\"r}ger's base compounds.",

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AU - Craig, Donald C.

AU - Try, Andrew C.

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AB - The one-step synthesis of a series of hybrid dibenzo Tr̈ger's base analogues bearing at least one halogen atom is described. The strategy involves a reaction between two different anilines and affords hybrid compounds in yields as high as 46%, together with the symmetric Tr̈ger's base products. This straightforward approach requires only one chromatographic step and has the potential to replace multi-step approaches to hybrid Tr̈ger's base compounds.

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One-step synthesis of tr̈ger's base hybrids containing at least one halogen atom

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