One-step synthesis of tr̈ger's base hybrids containing at least one halogen atom

Masoud Faroughi, Kai Xian Zhu, Paul Jensen, Donald C. Craig, Andrew C. Try

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The one-step synthesis of a series of hybrid dibenzo Tr̈ger's base analogues bearing at least one halogen atom is described. The strategy involves a reaction between two different anilines and affords hybrid compounds in yields as high as 46%, together with the symmetric Tr̈ger's base products. This straightforward approach requires only one chromatographic step and has the potential to replace multi-step approaches to hybrid Tr̈ger's base compounds.

Original languageEnglish
Pages (from-to)4266-4272
Number of pages7
JournalEuropean Journal of Organic Chemistry
Issue number25
DOIs
Publication statusPublished - Sep 2009

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