One-step synthesis of tr̈ger's base hybrids containing at least one halogen atom

Masoud Faroughi; Kai Xian Zhu; Paul Jensen; Donald C. Craig; Andrew C. Try

doi:10.1002/ejoc.200900121

One-step synthesis of tr̈ger's base hybrids containing at least one halogen atom

Masoud Faroughi, Kai Xian Zhu, Paul Jensen, Donald C. Craig, Andrew C. Try

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

The one-step synthesis of a series of hybrid dibenzo Tr̈ger's base analogues bearing at least one halogen atom is described. The strategy involves a reaction between two different anilines and affords hybrid compounds in yields as high as 46%, together with the symmetric Tr̈ger's base products. This straightforward approach requires only one chromatographic step and has the potential to replace multi-step approaches to hybrid Tr̈ger's base compounds.

Original language	English
Pages (from-to)	4266-4272
Number of pages	7
Journal	European Journal of Organic Chemistry
Issue number	25
DOIs	https://doi.org/10.1002/ejoc.200900121
Publication status	Published - Sept 2009

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title = "One-step synthesis of t{\"r}ger's base hybrids containing at least one halogen atom",

abstract = "The one-step synthesis of a series of hybrid dibenzo T{\"r}ger's base analogues bearing at least one halogen atom is described. The strategy involves a reaction between two different anilines and affords hybrid compounds in yields as high as 46\%, together with the symmetric T{\"r}ger's base products. This straightforward approach requires only one chromatographic step and has the potential to replace multi-step approaches to hybrid T{\"r}ger's base compounds.",

author = "Masoud Faroughi and Zhu, \{Kai Xian\} and Paul Jensen and Craig, \{Donald C.\} and Try, \{Andrew C.\}",

year = "2009",

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language = "English",

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journal = "European Journal of Organic Chemistry",

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AU - Faroughi, Masoud

AU - Zhu, Kai Xian

AU - Jensen, Paul

AU - Craig, Donald C.

AU - Try, Andrew C.

PY - 2009/9

Y1 - 2009/9

N2 - The one-step synthesis of a series of hybrid dibenzo Tr̈ger's base analogues bearing at least one halogen atom is described. The strategy involves a reaction between two different anilines and affords hybrid compounds in yields as high as 46%, together with the symmetric Tr̈ger's base products. This straightforward approach requires only one chromatographic step and has the potential to replace multi-step approaches to hybrid Tr̈ger's base compounds.

AB - The one-step synthesis of a series of hybrid dibenzo Tr̈ger's base analogues bearing at least one halogen atom is described. The strategy involves a reaction between two different anilines and affords hybrid compounds in yields as high as 46%, together with the symmetric Tr̈ger's base products. This straightforward approach requires only one chromatographic step and has the potential to replace multi-step approaches to hybrid Tr̈ger's base compounds.

UR - https://www.scopus.com/pages/publications/68949128666

U2 - 10.1002/ejoc.200900121

DO - 10.1002/ejoc.200900121

M3 - Article

AN - SCOPUS:68949128666

SN - 1434-193X

SP - 4266

EP - 4272

JO - European Journal of Organic Chemistry

JF - European Journal of Organic Chemistry

IS - 25

ER -

One-step synthesis of tr̈ger's base hybrids containing at least one halogen atom

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