Ophthalmological consequences of cyanotic congenital heart disease: vascular parameters and nerve fibre layer

Rachael Cordina; John Leaney; Mojtaba Golzan; Stuart Grieve; David S. Celermajer; Stuart L. Graham

doi:10.1111/ceo.12401

Ophthalmological consequences of cyanotic congenital heart disease: vascular parameters and nerve fibre layer

Rachael Cordina, John Leaney, Mojtaba Golzan, Stuart Grieve, David S. Celermajer, Stuart L. Graham^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Background: This study investigated the long-term ophthalmological consequences of cyanotic congenital heart disease (CHD).

Design: Cross-sectional study, tertiary referral setting.

Participants: Thirteen adults with cyanotic CHD (40 ± 4 years). Age- and sex-matched healthy controls underwent aspects of the protocol.

Methods: Cyanosed subjects had a full ophthalmic examination, visual fields, scanning laser ophthalmoscopy and optical coherence tomography to assess retinal nerve fibre layer (RNFL), retinal photography and cerebral magnetic resonance imaging (MRI).

Main Outcome Measures: RNFL thickness and quantitative analysis of retinal vessels with fractal dimension, branching and central retinal arterial equivalent (CRAE) and central retinal venous equivalent (CRVE).

Results: No abnormalities of anatomy, motility, intraocular pressure or anterior segments were detected apart from one subject who had bilateral cataracts. Corrected visual acuity was normal in all but one cyanosed subject. Clinical examination revealed dilated retinal vasculature in 12/13 cyanosed subjects and increased tortuosity in 8/13. In the setting of cyanosis, skeletonized retinal arterial and venous beds had higher fractal dimension and increased branching (P ≤ 0.01, n = 11 for all); retinal vessels were dilated (CRAE: 227 vs. 183, n = 11, P < 0.0001; CRVE: 254 vs. 221, n = 11, P = 0.01). Visual fields showed scotomas in two subjects associated with RNFL thinning. No disc oedema was detected. 6/13 subjects' RNFL thickness fell below the normal 95% confidence interval in at least one sector without explanatory cerebral pathology (P < 0.0001, n = 13). Mean RNFL thickness correlated with MRI cerebral white matter volume (R = 0.67, P = 0.035).

Conclusions: Cyanosed subjects had vessel dilatation, increased branching and tortuosity. RNFL and visual field thresholds were reduced suggesting impaired neuro-ophthalmological functioning.

Original language	English
Pages (from-to)	115-123
Number of pages	9
Journal	Clinical and Experimental Ophthalmology
Volume	43
Issue number	2
DOIs	https://doi.org/10.1111/ceo.12401
Publication status	Published - 1 Mar 2015

Keywords

cardiovascular disease
retina
retinal pathology
retinal vessel
visual field

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10.1111/ceo.12401

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title = "Ophthalmological consequences of cyanotic congenital heart disease: vascular parameters and nerve fibre layer",

abstract = "Background: This study investigated the long-term ophthalmological consequences of cyanotic congenital heart disease (CHD).Design: Cross-sectional study, tertiary referral setting.Participants: Thirteen adults with cyanotic CHD (40 ± 4 years). Age- and sex-matched healthy controls underwent aspects of the protocol.Methods: Cyanosed subjects had a full ophthalmic examination, visual fields, scanning laser ophthalmoscopy and optical coherence tomography to assess retinal nerve fibre layer (RNFL), retinal photography and cerebral magnetic resonance imaging (MRI).Main Outcome Measures: RNFL thickness and quantitative analysis of retinal vessels with fractal dimension, branching and central retinal arterial equivalent (CRAE) and central retinal venous equivalent (CRVE).Results: No abnormalities of anatomy, motility, intraocular pressure or anterior segments were detected apart from one subject who had bilateral cataracts. Corrected visual acuity was normal in all but one cyanosed subject. Clinical examination revealed dilated retinal vasculature in 12/13 cyanosed subjects and increased tortuosity in 8/13. In the setting of cyanosis, skeletonized retinal arterial and venous beds had higher fractal dimension and increased branching (P ≤ 0.01, n = 11 for all); retinal vessels were dilated (CRAE: 227 vs. 183, n = 11, P < 0.0001; CRVE: 254 vs. 221, n = 11, P = 0.01). Visual fields showed scotomas in two subjects associated with RNFL thinning. No disc oedema was detected. 6/13 subjects' RNFL thickness fell below the normal 95% confidence interval in at least one sector without explanatory cerebral pathology (P < 0.0001, n = 13). Mean RNFL thickness correlated with MRI cerebral white matter volume (R = 0.67, P = 0.035).Conclusions: Cyanosed subjects had vessel dilatation, increased branching and tortuosity. RNFL and visual field thresholds were reduced suggesting impaired neuro-ophthalmological functioning.",

keywords = "cardiovascular disease, retina, retinal pathology, retinal vessel, visual field",

author = "Rachael Cordina and John Leaney and Mojtaba Golzan and Stuart Grieve and Celermajer, {David S.} and Graham, {Stuart L.}",

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Ophthalmological consequences of cyanotic congenital heart disease : vascular parameters and nerve fibre layer. / Cordina, Rachael; Leaney, John; Golzan, Mojtaba; Grieve, Stuart; Celermajer, David S.; Graham, Stuart L.

In: Clinical and Experimental Ophthalmology, Vol. 43, No. 2, 01.03.2015, p. 115-123.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Ophthalmological consequences of cyanotic congenital heart disease

T2 - vascular parameters and nerve fibre layer

AU - Cordina, Rachael

AU - Leaney, John

AU - Golzan, Mojtaba

AU - Grieve, Stuart

AU - Celermajer, David S.

AU - Graham, Stuart L.

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N2 - Background: This study investigated the long-term ophthalmological consequences of cyanotic congenital heart disease (CHD).Design: Cross-sectional study, tertiary referral setting.Participants: Thirteen adults with cyanotic CHD (40 ± 4 years). Age- and sex-matched healthy controls underwent aspects of the protocol.Methods: Cyanosed subjects had a full ophthalmic examination, visual fields, scanning laser ophthalmoscopy and optical coherence tomography to assess retinal nerve fibre layer (RNFL), retinal photography and cerebral magnetic resonance imaging (MRI).Main Outcome Measures: RNFL thickness and quantitative analysis of retinal vessels with fractal dimension, branching and central retinal arterial equivalent (CRAE) and central retinal venous equivalent (CRVE).Results: No abnormalities of anatomy, motility, intraocular pressure or anterior segments were detected apart from one subject who had bilateral cataracts. Corrected visual acuity was normal in all but one cyanosed subject. Clinical examination revealed dilated retinal vasculature in 12/13 cyanosed subjects and increased tortuosity in 8/13. In the setting of cyanosis, skeletonized retinal arterial and venous beds had higher fractal dimension and increased branching (P ≤ 0.01, n = 11 for all); retinal vessels were dilated (CRAE: 227 vs. 183, n = 11, P < 0.0001; CRVE: 254 vs. 221, n = 11, P = 0.01). Visual fields showed scotomas in two subjects associated with RNFL thinning. No disc oedema was detected. 6/13 subjects' RNFL thickness fell below the normal 95% confidence interval in at least one sector without explanatory cerebral pathology (P < 0.0001, n = 13). Mean RNFL thickness correlated with MRI cerebral white matter volume (R = 0.67, P = 0.035).Conclusions: Cyanosed subjects had vessel dilatation, increased branching and tortuosity. RNFL and visual field thresholds were reduced suggesting impaired neuro-ophthalmological functioning.

AB - Background: This study investigated the long-term ophthalmological consequences of cyanotic congenital heart disease (CHD).Design: Cross-sectional study, tertiary referral setting.Participants: Thirteen adults with cyanotic CHD (40 ± 4 years). Age- and sex-matched healthy controls underwent aspects of the protocol.Methods: Cyanosed subjects had a full ophthalmic examination, visual fields, scanning laser ophthalmoscopy and optical coherence tomography to assess retinal nerve fibre layer (RNFL), retinal photography and cerebral magnetic resonance imaging (MRI).Main Outcome Measures: RNFL thickness and quantitative analysis of retinal vessels with fractal dimension, branching and central retinal arterial equivalent (CRAE) and central retinal venous equivalent (CRVE).Results: No abnormalities of anatomy, motility, intraocular pressure or anterior segments were detected apart from one subject who had bilateral cataracts. Corrected visual acuity was normal in all but one cyanosed subject. Clinical examination revealed dilated retinal vasculature in 12/13 cyanosed subjects and increased tortuosity in 8/13. In the setting of cyanosis, skeletonized retinal arterial and venous beds had higher fractal dimension and increased branching (P ≤ 0.01, n = 11 for all); retinal vessels were dilated (CRAE: 227 vs. 183, n = 11, P < 0.0001; CRVE: 254 vs. 221, n = 11, P = 0.01). Visual fields showed scotomas in two subjects associated with RNFL thinning. No disc oedema was detected. 6/13 subjects' RNFL thickness fell below the normal 95% confidence interval in at least one sector without explanatory cerebral pathology (P < 0.0001, n = 13). Mean RNFL thickness correlated with MRI cerebral white matter volume (R = 0.67, P = 0.035).Conclusions: Cyanosed subjects had vessel dilatation, increased branching and tortuosity. RNFL and visual field thresholds were reduced suggesting impaired neuro-ophthalmological functioning.

KW - cardiovascular disease

KW - retina

KW - retinal pathology

KW - retinal vessel

KW - visual field

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JO - Clinical and Experimental Ophthalmology

JF - Clinical and Experimental Ophthalmology

SN - 1442-6404

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Ophthalmological consequences of cyanotic congenital heart disease: vascular parameters and nerve fibre layer

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