Optical diagnostic of breast cancer using Raman, polarimetric and fluorescence spectroscopy

Shahzad Anwar, Shamaraz Firdous, Aziz Ul Rehman, Muhammed Nawaz

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

We presented the optical diagnostic of normal and cancerous human breast tissues using Raman, polarimetric and fluorescence spectroscopic techniques. Breast cancer is the second leading cause of cancer death among women worldwide. Optical diagnostics of cancer offered early intervention and the greatest chance of cure. Spectroscopic data were collected from freshly excised surgical specimens of normal tissues with Raman bands at 800, 1171 and 1530 cm-1 arising mainly by lipids, nucleic acids, proteins, carbohydrates and amino acids. For breast cancer, Raman bands are observed at 1070, 1211, 1495, 1583 and 1650 cm-1. Results demonstrate that the spectra of normal tissue are dominated by lipids and amino acids. Polarization decomposition of the Mueller matrix and confocal microscopic fluorescence provides detailed description of cancerous tissue and distinguishes between the normal and malignant one. Based on these findings, we successfully differentiate normal and malignant breast tissues at an early stage of disease. There is a need to develop a new tool for noninvasive, real-time diagnosis of tissue abnormalities and a test procedure for detecting breast cancer at an early stage.

Original languageEnglish
Article number045601
Pages (from-to)1-6
Number of pages6
JournalLaser Physics Letters
Volume12
Issue number4
DOIs
Publication statusPublished - 1 Apr 2015

Keywords

  • breast cancer
  • confocal microscopy
  • Mueller matrix
  • optical diagnosis
  • polarimetry
  • Raman spectroscopy
  • tissue scattering

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