Optimization of simultaneous emission and transmission measurements in PET

Steven R. Meikle*, Dale L. Bailey, Brian F. Hutton, William F. Jones

*Corresponding author for this work

    Research output: Chapter in Book/Report/Conference proceedingConference proceeding contribution

    2 Citations (Scopus)

    Abstract

    Sinogram windowing of rotating rod sources allows the possibility of simultaneously acquiring emission and transmission data. While transmission signal to noise ratio (SNR) is improved, mainly due to rejection of random coincidences, they account for a large fraction of emission prompts, severely limiting emission SNR. We have investigated three methods for optimizing SNR in these measurements. Firstly, transmission SNR can be traded off by reducing rod source activity, resulting in a reduced randoms rate. Secondly, noise in the randoms histogram can be reduced using Casey processing. Thirdly, segmented attenuation correction (SAC) can be applied to simultaneously acquired transmission data to minimize propagation of noise. Rod activity can be reduced by a factor of 4 without loss of SNR compared with a non windowed transmission study. As rod activity decreases, the incremental improvement in SNR decreases using Casey processing and increases using SAC. Using low activity rods and SAC, there is less than 10% difference in SNR between simultaneous and separate measurements. Initial results of total body PET studies are presented employing the methods described combined with accelerated EM reconstruction.

    Original languageEnglish
    Title of host publicationIEEE Nuclear Science Symposium & Medical Imaging Conference
    PublisherInstitute of Electrical and Electronics Engineers (IEEE)
    Pages1642-1646
    Number of pages5
    Editionpt 3
    ISBN (Print)0780314875
    Publication statusPublished - 1994
    EventProceedings of the 1993 IEEE Nuclear Science Symposium & Medical Imaging Conference - San Francisco, CA, USA
    Duration: 30 Oct 19936 Nov 1993

    Other

    OtherProceedings of the 1993 IEEE Nuclear Science Symposium & Medical Imaging Conference
    CitySan Francisco, CA, USA
    Period30/10/936/11/93

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