Optimizing breast pocket irrigation: the breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) era

Eric J. Culbertson, Christina Felder-Scott, Anand K. Deva, David E. Greenberg, William P. Adams

    Research output: Contribution to journalArticlepeer-review

    14 Citations (Scopus)

    Abstract

    Background: Specific antimicrobial breast pocket irrigations have been proven over the past 20 years to reduce the incidence of capsular contracture by a factor of 10, and the emergence of breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) and its link to bacteria/technique has created renewed interest in different antimicrobial breast pocket preparation agents. Our previous studies have identified that both Betadine-containing and non-Betadine-containing antimicrobial irrigations provide excellent broad-spectrum bacterial coverage. The current science of BIA-ALCL has implicated the Gram-negative microbiome as a key in pathogenesis.

    Objectives: The aim of this study was to revisit the antimicrobial effectiveness of clinically utilized Betadine and non-Betadine solutions, along with other antimicrobial agents that have not yet been tested, against multiple organisms, including additional common Gram-negative bacteria associated with chronic breast implant infections/inflammation.

    Methods: Current and new antimicrobial breast irrigations were tested via standard techniques for bactericidal activity against multiple Gram-positive and Gram-negative strains. Test results are detailed and clinical recommendations for current antimicrobial irrigations are provided.

    Results: Betadine-containing irrigations were found to be superior according to the testing performed.

    Conclusions: There are quite few misconceptions with regard to antimicrobial breast pocket irrigation. These are discussed and final evidence-based recommendations for practice are given.

    Original languageEnglish
    Pages (from-to)619-625
    Number of pages7
    JournalAesthetic Surgery Journal
    Volume40
    Issue number6
    Early online date10 Sep 2019
    DOIs
    Publication statusPublished - 16 May 2020

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