TY - JOUR
T1 - Oral epithelial dysplasia
T2 - a review of diagnostic criteria for anatomic pathologists
AU - Cheung, Veronica K. Y.
AU - Hulme, Katherine
AU - Schifter, Mark
AU - Palme, Carsten
AU - Low, Tsu-Hui (Hubert)
AU - Clark, Jonathan
AU - Gupta, Ruta
PY - 2022/7/1
Y1 - 2022/7/1
N2 - Oral epithelial dysplasia (OED) represents a spectrum of histologic changes in the oral cavity mucosa that has the potential to transform into oral squamous cell carcinoma. Predicting the risk of malignant transformation is predominantly based on clinicopathologic correlation, histologic examination and grading. OED often poses a diagnostic challenge, primarily due to its histologic mimics and a large number of terminologies used in the literature. The grading system for OED is also fraught with significant interobserver variability. This review summarizes the essential clinical and histopathologic features of OED and its mimics. Practical preanalytical, analytical, and postanalytical considerations for anatomic pathologists are discussed to improve the diagnostic accuracy and increase the reproducibility in the grading of OED.
AB - Oral epithelial dysplasia (OED) represents a spectrum of histologic changes in the oral cavity mucosa that has the potential to transform into oral squamous cell carcinoma. Predicting the risk of malignant transformation is predominantly based on clinicopathologic correlation, histologic examination and grading. OED often poses a diagnostic challenge, primarily due to its histologic mimics and a large number of terminologies used in the literature. The grading system for OED is also fraught with significant interobserver variability. This review summarizes the essential clinical and histopathologic features of OED and its mimics. Practical preanalytical, analytical, and postanalytical considerations for anatomic pathologists are discussed to improve the diagnostic accuracy and increase the reproducibility in the grading of OED.
KW - dysplasia
KW - erythroleukoplakia
KW - grade
KW - leukoplakia
KW - oral epithelial dysplasia
KW - oral potentially malignant disorders
UR - http://www.scopus.com/inward/record.url?scp=85129466758&partnerID=8YFLogxK
U2 - 10.1097/PAP.0000000000000343
DO - 10.1097/PAP.0000000000000343
M3 - Review article
C2 - 35435865
SN - 1072-4109
VL - 29
SP - 227
EP - 240
JO - Advances in Anatomic Pathology
JF - Advances in Anatomic Pathology
IS - 4
ER -