Os-2-Os-4 Switch Controls DNA Knotting and Anticancer Activity

Ying Fu, María J. Romero, Luca Salassa, Xi Cheng, Abraha Habtemariam, Guy J. Clarkson, Ivan Prokes, Alison Rodger, Giovanni Costantini, Peter J. Sadler*

*Corresponding author for this work

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Dinuclear trihydroxido-bridged osmium–arene complexes are inert and biologically inactive, but we show here that linking dihydroxido-bridged OsII–arene fragments by a bridging di-imine to form a metallacycle framework results in strong antiproliferative activity towards cancer cells and distinctive knotting of DNA. The shortened spacer length reduces biological activity and stability in solution towards decomposition to biologically inactive dimers. Significant differences in behavior toward plasmid DNA condensation are correlated with biological activity.

Original languageEnglish
Pages (from-to)8909-8912
Number of pages4
JournalAngewandte Chemie - International Edition
Volume55
Issue number31
DOIs
Publication statusPublished - 25 Jul 2016
Externally publishedYes

Bibliographical note

Copyright the Author(s) 2016. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • cancer
  • DNA
  • organometallic
  • osmium
  • supramolecular

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