Osteoporosis influences the early period of fracture healing in a rat osteoporotic model

H. Namkung-Matthai, R. Appleyard, J. Jansen, J. Hao Lin, S. Maastricht, M. Swain, R. S. Mason, G. A.C. Murrell, A. D. Diwan, T. Diamond*

*Corresponding author for this work

Research output: Contribution to journalArticle

300 Citations (Scopus)

Abstract

Osteoporotic fractures commonly occur in the elderly. Although current therapies are aimed at the prevention and treatment of osteoporotic fractures, studies examing the fracture healing process in osteoporotic bone are limited. We produced an osteoporotic rat model by ovariectomy (ovx) and maintained a low calcium diet (LCD) in order to evaluate the influence of osteoporosis on fracture healing. Callus formation and strength was monitored over a 3 week period by histological and biomechanical assessment. Data collected simultaneously on a group of rats undergoing sham surgery (sx) were used for comparison. A 40% reduction in fracture callus cross-sectional area and a 23% reduction in bone mineral density in the healing femur of the ovx rats was observed on day 21 following fracture as compared with the sx group (p < 0.01). Biomechanical data from the healing femur of the ovx rats revealed a fivefold decrease in the energy required to break the fracture callus, a threefold decrease in peak failure load, a twofold decrease in stiffness and a threefold decrease in stress as compared with the sx group (p < 0.01, respectively). Histomorphological analysis revealed a delay in fracture callus healing with poor development of mature bone in the ovx rats. This study provides physical evidence of altered fracture healing in osteoporotic bone, which may have important implications in evaluating the effects of new treatments for osteoporosis on fracture healing.

Original languageEnglish
Pages (from-to)80-86
Number of pages7
JournalBone
Volume28
Issue number1
DOIs
Publication statusPublished - 2001
Externally publishedYes

Keywords

  • Bone
  • Estrogen deficiency
  • Femoral neck
  • Fracture
  • Healing
  • Osteoporosis

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