Osteoporosis is inversely associated with arterial stiffness in the elderly

an investigation using the Osteoporosis Self-assessment Tool for Asians index in an elderly Chinese cohort

Yan Xuan, Weiliang Wang, Hong Zhang, Isabella Tan, Mark Butlin, Alberto Avolio, Junli Zuo*

*Corresponding author for this work

Research output: Contribution to journalArticle


Although the association of arterial stiffness and osteoporosis has been reported, the relation of arterial stiffness with risk of osteoporosis and bone fracture is not established. The authors investigated the correlation between arterial stiffness (brachial-ankle pulse wave velocity [baPWV]), including a cutoff value, and risk of osteoporosis as assessed by the Osteoporosis Self-assessment Tool for Asia (OSTA) index in 129 elderly Chinese community-dwelling individuals (age 83.2 ± 12.8 years, 63 females). OSTA was negatively correlated with baPWV (r = −0.326, P = 0.023) after adjusting for confounding factors such as gender, body mass index, low-density lipoprotein, triglycerides, estimated glomerular filtration rate, absence or presence of diabetes, absence or presence of hypertension, and uric acid. baPWV was an independent factor for changes in OSTA (β = −0.001, P = 0.002). ROC curve analysis confirmed association between baPWV and OSTA index (AUC = 0.742 [CI: 0.660, 0.824]; P < 0.001) with a baPWV cutoff value of 1676 cm/s (sensitivity, 80.7%; specificity, 60%) for prediction of high OSTA index. The study showed a significant correlation between OSTA index and baPWV, suggesting a potential predictive value of baPWV in elderly patient at high risk of osteoporosis.

Original languageEnglish
Pages (from-to)405-411
Number of pages7
JournalJournal of Clinical Hypertension
Issue number3
Early online date7 Feb 2019
Publication statusPublished - 1 Mar 2019



  • arterial stiffness
  • bone mineral density
  • osteoporosis
  • pulse wave velocity

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