Outcome for middle cerebral artery aneurysm surgery

Michael K. Morgan, Wattana Mahattanakul, Andrew Davidson, John Reid

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Objective: To assess in depth the variables contributing to adverse surgical outcome for repair of unruptured middle cerebral artery aneurysms. Methods: Prospectively collected data between October 1989 and June 2009 were examined retrospectively. Putative risk factors were investigated with univariate and multivariate logistic regression analyses. Results: In this study, 263 patients (339 aneurysms) underwent surgical clipping in 280 operations for unruptured middle cerebral artery aneurysms. The overall surgical mortality and morbidity rate was 5% (95% confidence interval [CI], 2.9-8.3). Multivariate logistic analysis of risk factors revealed that age and aneurysm size were independent predictors of surgical outcome. Patients < 60 years of age with an aneurysm ≤ 12 mm constituted a low-risk group with a procedure-related combined mortality and morbidity of 0.6% (95% CI, 0-3.8). Patients < 60 years of age with an aneurysm > 12 mm had a procedure-related combined mortality and morbidity of 7.4% (95% CI, 1-24.5). Patients ≥ 60 years of age with an aneurysm of ≤ 12 mm had a procedure-related combined mortality and morbidity of 9.3% (95% CI, 4.3-18.3). Patients ≥ 60 years of age with an aneurysm > 12 mm had a procedure-related combined mortality and morbidity of 22.2% (95% CI, 8.5-45.8). Conclusion: Age and size of aneurysm were the only 2 independent predictors of surgical outcome.

LanguageEnglish
Pages755-761
Number of pages7
JournalNeurosurgery
Volume67
Issue number3
DOIs
Publication statusPublished - Sep 2010

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Intracranial Aneurysm
Aneurysm
Confidence Intervals
Morbidity
Mortality
Multivariate Analysis
Logistic Models
Regression Analysis

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Morgan, Michael K. ; Mahattanakul, Wattana ; Davidson, Andrew ; Reid, John. / Outcome for middle cerebral artery aneurysm surgery. In: Neurosurgery. 2010 ; Vol. 67, No. 3. pp. 755-761.
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Outcome for middle cerebral artery aneurysm surgery. / Morgan, Michael K.; Mahattanakul, Wattana; Davidson, Andrew; Reid, John.

In: Neurosurgery, Vol. 67, No. 3, 09.2010, p. 755-761.

Research output: Contribution to journalArticleResearchpeer-review

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