Abstract
Objective: To assess in depth the variables contributing to adverse surgical outcome for repair of unruptured middle cerebral artery aneurysms. Methods: Prospectively collected data between October 1989 and June 2009 were examined retrospectively. Putative risk factors were investigated with univariate and multivariate logistic regression analyses. Results: In this study, 263 patients (339 aneurysms) underwent surgical clipping in 280 operations for unruptured middle cerebral artery aneurysms. The overall surgical mortality and morbidity rate was 5% (95% confidence interval [CI], 2.9-8.3). Multivariate logistic analysis of risk factors revealed that age and aneurysm size were independent predictors of surgical outcome. Patients < 60 years of age with an aneurysm ≤ 12 mm constituted a low-risk group with a procedure-related combined mortality and morbidity of 0.6% (95% CI, 0-3.8). Patients < 60 years of age with an aneurysm > 12 mm had a procedure-related combined mortality and morbidity of 7.4% (95% CI, 1-24.5). Patients ≥ 60 years of age with an aneurysm of ≤ 12 mm had a procedure-related combined mortality and morbidity of 9.3% (95% CI, 4.3-18.3). Patients ≥ 60 years of age with an aneurysm > 12 mm had a procedure-related combined mortality and morbidity of 22.2% (95% CI, 8.5-45.8). Conclusion: Age and size of aneurysm were the only 2 independent predictors of surgical outcome.
| Language | English |
|---|---|
| Pages | 755-761 |
| Number of pages | 7 |
| Journal | Neurosurgery |
| Volume | 67 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Sep 2010 |
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Outcome for middle cerebral artery aneurysm surgery. / Morgan, Michael K.; Mahattanakul, Wattana; Davidson, Andrew; Reid, John.
In: Neurosurgery, Vol. 67, No. 3, 09.2010, p. 755-761.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Outcome for middle cerebral artery aneurysm surgery
AU - Morgan, Michael K.
AU - Mahattanakul, Wattana
AU - Davidson, Andrew
AU - Reid, John
PY - 2010/9
Y1 - 2010/9
N2 - Objective: To assess in depth the variables contributing to adverse surgical outcome for repair of unruptured middle cerebral artery aneurysms. Methods: Prospectively collected data between October 1989 and June 2009 were examined retrospectively. Putative risk factors were investigated with univariate and multivariate logistic regression analyses. Results: In this study, 263 patients (339 aneurysms) underwent surgical clipping in 280 operations for unruptured middle cerebral artery aneurysms. The overall surgical mortality and morbidity rate was 5% (95% confidence interval [CI], 2.9-8.3). Multivariate logistic analysis of risk factors revealed that age and aneurysm size were independent predictors of surgical outcome. Patients < 60 years of age with an aneurysm ≤ 12 mm constituted a low-risk group with a procedure-related combined mortality and morbidity of 0.6% (95% CI, 0-3.8). Patients < 60 years of age with an aneurysm > 12 mm had a procedure-related combined mortality and morbidity of 7.4% (95% CI, 1-24.5). Patients ≥ 60 years of age with an aneurysm of ≤ 12 mm had a procedure-related combined mortality and morbidity of 9.3% (95% CI, 4.3-18.3). Patients ≥ 60 years of age with an aneurysm > 12 mm had a procedure-related combined mortality and morbidity of 22.2% (95% CI, 8.5-45.8). Conclusion: Age and size of aneurysm were the only 2 independent predictors of surgical outcome.
AB - Objective: To assess in depth the variables contributing to adverse surgical outcome for repair of unruptured middle cerebral artery aneurysms. Methods: Prospectively collected data between October 1989 and June 2009 were examined retrospectively. Putative risk factors were investigated with univariate and multivariate logistic regression analyses. Results: In this study, 263 patients (339 aneurysms) underwent surgical clipping in 280 operations for unruptured middle cerebral artery aneurysms. The overall surgical mortality and morbidity rate was 5% (95% confidence interval [CI], 2.9-8.3). Multivariate logistic analysis of risk factors revealed that age and aneurysm size were independent predictors of surgical outcome. Patients < 60 years of age with an aneurysm ≤ 12 mm constituted a low-risk group with a procedure-related combined mortality and morbidity of 0.6% (95% CI, 0-3.8). Patients < 60 years of age with an aneurysm > 12 mm had a procedure-related combined mortality and morbidity of 7.4% (95% CI, 1-24.5). Patients ≥ 60 years of age with an aneurysm of ≤ 12 mm had a procedure-related combined mortality and morbidity of 9.3% (95% CI, 4.3-18.3). Patients ≥ 60 years of age with an aneurysm > 12 mm had a procedure-related combined mortality and morbidity of 22.2% (95% CI, 8.5-45.8). Conclusion: Age and size of aneurysm were the only 2 independent predictors of surgical outcome.
UR - http://www.scopus.com/inward/record.url?scp=77956188018&partnerID=8YFLogxK
U2 - 10.1227/01.NEU.0000378025.33899.26
DO - 10.1227/01.NEU.0000378025.33899.26
M3 - Article
VL - 67
SP - 755
EP - 761
JO - Neurosurgery
T2 - Neurosurgery
JF - Neurosurgery
SN - 0148-396X
IS - 3
ER -