Outcomes and predicting response in anaemic chemotherapy patients treated with epoetin alfa. A multicentre, 4-month, open-label study in Australia and New Zealand

D. Bell, D. Grimes, H. Gurney, D. Dalley, T. Blackwell, R. Fox, M. Jeffery

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background: The aim of the study was to evaluate the effectiveness, safety, and clinical outcomes of erythropoietin therapy in the treatment of anaemic cancer subjects receiving chemotherapy and to examine hypochromic red blood cell measurement as an indicator of functional iron sufficiency and as a predictor of responsiveness or non-responsiveness to erythropoietin therapy. Methods: Patients who had a non-myeloid malignancy, had Hb ≤ 11.0 g/dL, had a life expectancy of more than 6 months, were 18 years or older, were receiving chemotherapy and would continue to be treated for at least 2 months were given s.c. epoetin alfa three times a week. Results: Haemoglobin levels increased significantly at all time periods compared with baseline and the number of transfusions received decreased significantly at all time periods compared with baseline. Quality of life as measured by Functional Assessment of Cancer Therapy-Anaemia showed significant increases at months 2 and 4 and there were significant improvements in the fatigue subscale at both time points (P < 0.05). Significant improvements at end-point were observed for the physical, emotional and functional well-being, and additional concern subscales (all P < 0.05). Haematocrit and reticulocytes increased significantly at end-point compared with at baseline (haematocrit 33.4 vs 28.3%, P < 0.001; reticulocytes 105.8 vs 78.6 × 109/dL, P = 0.005). The percentage of hypochromic red blood cells did not show predictive value for response to treatment status. Conclusion: Epoetin alfa improved haemoglobin levels and quality of life in anaemic cancer patients receiving chemotherapy.

LanguageEnglish
Pages751-757
Number of pages7
JournalInternal Medicine Journal
Volume38
Issue number10
DOIs
Publication statusPublished - Oct 2008
Externally publishedYes

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Epoetin Alfa
New Zealand
Drug Therapy
Reticulocytes
Erythropoietin
Hematocrit
Neoplasms
Hemoglobins
Erythrocytes
Quality of Life
Therapeutics
Life Expectancy
Fatigue
Anemia
Iron
Safety

Cite this

@article{41f488a65fa448d0ba4696c3d1aa55d9,
title = "Outcomes and predicting response in anaemic chemotherapy patients treated with epoetin alfa. A multicentre, 4-month, open-label study in Australia and New Zealand",
abstract = "Background: The aim of the study was to evaluate the effectiveness, safety, and clinical outcomes of erythropoietin therapy in the treatment of anaemic cancer subjects receiving chemotherapy and to examine hypochromic red blood cell measurement as an indicator of functional iron sufficiency and as a predictor of responsiveness or non-responsiveness to erythropoietin therapy. Methods: Patients who had a non-myeloid malignancy, had Hb ≤ 11.0 g/dL, had a life expectancy of more than 6 months, were 18 years or older, were receiving chemotherapy and would continue to be treated for at least 2 months were given s.c. epoetin alfa three times a week. Results: Haemoglobin levels increased significantly at all time periods compared with baseline and the number of transfusions received decreased significantly at all time periods compared with baseline. Quality of life as measured by Functional Assessment of Cancer Therapy-Anaemia showed significant increases at months 2 and 4 and there were significant improvements in the fatigue subscale at both time points (P < 0.05). Significant improvements at end-point were observed for the physical, emotional and functional well-being, and additional concern subscales (all P < 0.05). Haematocrit and reticulocytes increased significantly at end-point compared with at baseline (haematocrit 33.4 vs 28.3{\%}, P < 0.001; reticulocytes 105.8 vs 78.6 × 109/dL, P = 0.005). The percentage of hypochromic red blood cells did not show predictive value for response to treatment status. Conclusion: Epoetin alfa improved haemoglobin levels and quality of life in anaemic cancer patients receiving chemotherapy.",
author = "D. Bell and D. Grimes and H. Gurney and D. Dalley and T. Blackwell and R. Fox and M. Jeffery",
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Outcomes and predicting response in anaemic chemotherapy patients treated with epoetin alfa. A multicentre, 4-month, open-label study in Australia and New Zealand. / Bell, D.; Grimes, D.; Gurney, H.; Dalley, D.; Blackwell, T.; Fox, R.; Jeffery, M.

In: Internal Medicine Journal, Vol. 38, No. 10, 10.2008, p. 751-757.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Outcomes and predicting response in anaemic chemotherapy patients treated with epoetin alfa. A multicentre, 4-month, open-label study in Australia and New Zealand

AU - Bell, D.

AU - Grimes, D.

AU - Gurney, H.

AU - Dalley, D.

AU - Blackwell, T.

AU - Fox, R.

AU - Jeffery, M.

PY - 2008/10

Y1 - 2008/10

N2 - Background: The aim of the study was to evaluate the effectiveness, safety, and clinical outcomes of erythropoietin therapy in the treatment of anaemic cancer subjects receiving chemotherapy and to examine hypochromic red blood cell measurement as an indicator of functional iron sufficiency and as a predictor of responsiveness or non-responsiveness to erythropoietin therapy. Methods: Patients who had a non-myeloid malignancy, had Hb ≤ 11.0 g/dL, had a life expectancy of more than 6 months, were 18 years or older, were receiving chemotherapy and would continue to be treated for at least 2 months were given s.c. epoetin alfa three times a week. Results: Haemoglobin levels increased significantly at all time periods compared with baseline and the number of transfusions received decreased significantly at all time periods compared with baseline. Quality of life as measured by Functional Assessment of Cancer Therapy-Anaemia showed significant increases at months 2 and 4 and there were significant improvements in the fatigue subscale at both time points (P < 0.05). Significant improvements at end-point were observed for the physical, emotional and functional well-being, and additional concern subscales (all P < 0.05). Haematocrit and reticulocytes increased significantly at end-point compared with at baseline (haematocrit 33.4 vs 28.3%, P < 0.001; reticulocytes 105.8 vs 78.6 × 109/dL, P = 0.005). The percentage of hypochromic red blood cells did not show predictive value for response to treatment status. Conclusion: Epoetin alfa improved haemoglobin levels and quality of life in anaemic cancer patients receiving chemotherapy.

AB - Background: The aim of the study was to evaluate the effectiveness, safety, and clinical outcomes of erythropoietin therapy in the treatment of anaemic cancer subjects receiving chemotherapy and to examine hypochromic red blood cell measurement as an indicator of functional iron sufficiency and as a predictor of responsiveness or non-responsiveness to erythropoietin therapy. Methods: Patients who had a non-myeloid malignancy, had Hb ≤ 11.0 g/dL, had a life expectancy of more than 6 months, were 18 years or older, were receiving chemotherapy and would continue to be treated for at least 2 months were given s.c. epoetin alfa three times a week. Results: Haemoglobin levels increased significantly at all time periods compared with baseline and the number of transfusions received decreased significantly at all time periods compared with baseline. Quality of life as measured by Functional Assessment of Cancer Therapy-Anaemia showed significant increases at months 2 and 4 and there were significant improvements in the fatigue subscale at both time points (P < 0.05). Significant improvements at end-point were observed for the physical, emotional and functional well-being, and additional concern subscales (all P < 0.05). Haematocrit and reticulocytes increased significantly at end-point compared with at baseline (haematocrit 33.4 vs 28.3%, P < 0.001; reticulocytes 105.8 vs 78.6 × 109/dL, P = 0.005). The percentage of hypochromic red blood cells did not show predictive value for response to treatment status. Conclusion: Epoetin alfa improved haemoglobin levels and quality of life in anaemic cancer patients receiving chemotherapy.

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U2 - 10.1111/j.1445-5994.2008.01736.x

DO - 10.1111/j.1445-5994.2008.01736.x

M3 - Article

VL - 38

SP - 751

EP - 757

JO - Internal Medicine Journal

T2 - Internal Medicine Journal

JF - Internal Medicine Journal

SN - 1444-0903

IS - 10

ER -