Outcomes of Same-Sizing versus Oversizing Donor Trephines in Keratoconic Patients Undergoing First Penetrating Keratoplasty

Philip D. Jaycock*, Mark N A Jones, John Males, W. John Armitage, Stuart D. Cook, Derek M. Tole, Stephen B. Kaye

*Corresponding author for this work

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Purpose: To investigate whether use of same-size donor and recipient trephines reduced myopia after penetrating keratoplasty for keratoconus. Design: Retrospective cohort study. Participants: Eight hundred seventy-eight first grafts for keratoconus were reported to UK Transplant between April 1999 and December 2003. There were 234 and 644 grafts in the same-size and oversize donor trephine groups, respectively. At 1 year, mean spherical equivalent (SE) data were available for 116 eyes (50%) and 295 eyes (46%) in the same-size and oversize groups. At 2 years, mean SE data were available for 64 eyes (27%) and 148 eyes (23%) in the same-size and oversize groups. Methods: Logistic regression and univariate analysis of follow-up data submitted to UK Transplant. Main Outcome Measures: At 1 and 2 years postoperatively, mean SE, magnitude of the cylindrical component of the refraction, postoperative uncorrected visual acuity (VA), postoperative best-corrected VA, and postoperative complications were recorded. Results: The mean SEs for the same-size and oversize donor trephine groups, respectively, were -1.45 diopters (D) and -1.41 D at 1 year (P = 0.6) and -1.74 D and -2.19 D at 2 years postoperatively (P = 0.3). Although there were no differences in graft survival between the groups at 1 and 2 years, there was a higher incidence of postoperative wound leaks in the same-size group (P = 0.03). Conclusion: Use of same-size donor and recipient trephines did not reduce myopia and was associated with an increased risk of postoperative complications.

Original languageEnglish
Pages (from-to)268-275
Number of pages8
JournalOphthalmology
Volume115
Issue number2
DOIs
Publication statusPublished - Feb 2008

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    Jaycock, P. D., Jones, M. N. A., Males, J., Armitage, W. J., Cook, S. D., Tole, D. M., & Kaye, S. B. (2008). Outcomes of Same-Sizing versus Oversizing Donor Trephines in Keratoconic Patients Undergoing First Penetrating Keratoplasty. Ophthalmology, 115(2), 268-275. https://doi.org/10.1016/j.ophtha.2007.04.051