Oxidative arylation of isochroman

Soo J. Park, Jason R. Price, Matthew H. Todd

Research output: Contribution to journalArticlepeer-review

85 Citations (Scopus)

Abstract

We report the use of a previously intractable nucleophile, anisole, in an oxidative "cross-dehydrogenative coupling" (CDC) reaction with the cyclic ether isochroman, as well as derivatives of both components. Metal catalysis was required for the reaction to proceed efficiently, and the reaction is highly sensitive to modification of either coupling partner but is able to produce a range of novel compounds via what is a synthetic alternative to the traditional oxa-Pictet―Spengler reaction.
Original languageEnglish
Pages (from-to)949-955
Number of pages7
JournalJournal of Organic Chemistry
Volume77
Issue number2
DOIs
Publication statusPublished - 2012
Externally publishedYes

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