Oxidative stress in a rat model of chronic gliosis

Kristyn A. Bates*, Ralph N. Martins, Alan R. Harvey

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Alzheimer's disease is a progressive neurodegenerative disorder characterised by abnormal extracellular deposition of a 4 kDa peptide termed beta-amyloid, neuronal loss, oxidative stress and chronic astrocytosis and microgliosis, but how the latter two features contribute to the progression of the disease is poorly understood. We have previously demonstrated in a novel in vivo transplantation model that chronic astro- and microgliosis resulted in molecular pathology similar to that observed in the Alzheimer's disease brain. We now report that these heterotopic, gliotic transplants exhibit prolonged oxidative stress, characterised by lipid peroxidation and protein carbonyl formation. Furthermore, we demonstrate that dietary additives can elevate endogenous anti-oxidant defences and reduce oxidative stress without attenuating astro- and microgliosis. We also show that administration of ibuprofen through the drinking water results in a similar reduction in oxidative stress but with no observable effect on glial reactivity. The present study lends support to the notion that dietary anti-oxidants and non-steroidal anti-inflammatory drugs may be potential preventative agents against some of the pathological processes associated with neurodegenerative disease.

Original languageEnglish
Pages (from-to)995-1008
Number of pages14
JournalNeurobiology of Aging
Volume28
Issue number7
DOIs
Publication statusPublished - Jul 2007
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Anti-oxidants
  • Gliosis
  • Non-steroidal anti-inflammatory drugs
  • Oxidative stress

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