Paper-based bioactive scaffolds for stem cell-mediated bone tissue engineering

Hyun-Ji Park, Seung Jung Yu, Kisuk Yang, Yoonhee Jin, Ann-Na Cho, Jin Kim, Bora Lee, Hee Seok Yang, Sung Gap Im, Seung-Woo Cho

Research output: Contribution to journalArticlepeer-review

96 Citations (Scopus)


Bioactive, functional scaffolds are required to improve the regenerative potential of stem cells for tissue reconstruction and functional recovery of damaged tissues. Here, we report a paper-based bioactive scaffold platform for stem cell culture and transplantation for bone reconstruction. The paper scaffolds are surface-engineered by an initiated chemical vapor deposition process for serial coating of a water-repellent and cell-adhesive polymer film, which ensures the long-term stability in cell culture medium and induces efficient cell attachment. The prepared paper scaffolds are compatible with general stem cell culture and manipulation techniques. An optimal paper type is found to provide structural, physical, and mechanical cues to enhance the osteogenic differentiation of human adipose-derived stem cells (hADSCs). A bioactive paper scaffold significantly enhances in vivo bone regeneration of hADSCs in a critical-sized calvarial bone defect. Stacking the paper scaffolds with osteogenically differentiated hADSCs and human endothelial cells resulted in vascularized bone formation in vivo. Our study suggests that paper possesses great potential as a bioactive, functional, and cost-effective scaffold platform for stem cell-mediated bone tissue engineering. To the best of our knowledge, this is the first study reporting the feasibility of a paper material for stem cell application to repair tissue defects.
Original languageEnglish
Pages (from-to)9811-9823
Number of pages13
Issue number37
Publication statusPublished - Dec 2014
Externally publishedYes


  • Paper scaffold
  • Initiated chemical vapor deposition
  • Human adipose-derived stem cell
  • Osteogenic differentiation
  • Bone tissue engineering


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