Paracingulate sulcus morphology is associated with hallucinations in the human brain

Jane R. Garrison; Charles Fernyhough; Simon McCarthy-Jones; Mark Haggard; Vaughan Carr; Ulrich Schall; Rodney Scott; Assen Jablensky; Bryan Mowry; Patricia Michie; Stanley Catts; Frans Henskens; Christos Pantelis; Carmel Loughland; Jon S. Simons

doi:10.1038/ncomms9956

Paracingulate sulcus morphology is associated with hallucinations in the human brain

Jane R. Garrison, Charles Fernyhough, Simon McCarthy-Jones, Mark Haggard, Vaughan Carr, Ulrich Schall, Rodney Scott, Assen Jablensky, Bryan Mowry, Patricia Michie, Stanley Catts, Frans Henskens, Christos Pantelis, Carmel Loughland, Jon S. Simons^*

^*Corresponding author for this work

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Abstract

Hallucinations are common in psychiatric disorders, and are also experienced by many individuals who are not mentally ill. Here, in 153 participants, we investigate brain structural markers that predict the occurrence of hallucinations by comparing patients with schizophrenia who have experienced hallucinations against patients who have not, matched on a number of demographic and clinical variables. Using both newly validated visual classification techniques and automated, data-driven methods, hallucinations were associated with specific brain morphology differences in the paracingulate sulcus, a fold in the medial prefrontal cortex, with a 1cm reduction in sulcal length increasing the likelihood of hallucinations by 19.9%, regardless of the sensory modality in which they were experienced. The findings suggest a specific morphological basis for a pervasive feature of typical and atypical human experience.

Original language	English
Article number	8956
Pages (from-to)	1-6
Number of pages	6
Journal	Nature Communications
Volume	6
DOIs	https://doi.org/10.1038/ncomms9956
Publication status	Published - 17 Nov 2015

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Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

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Garrison, J. R., Fernyhough, C., McCarthy-Jones, S., Haggard, M., Carr, V., Schall, U., Scott, R., Jablensky, A., Mowry, B., Michie, P., Catts, S., Henskens, F., Pantelis, C., Loughland, C., & Simons, J. S. (2015). Paracingulate sulcus morphology is associated with hallucinations in the human brain. Nature Communications, 6, 1-6. Article 8956. https://doi.org/10.1038/ncomms9956

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abstract = "Hallucinations are common in psychiatric disorders, and are also experienced by many individuals who are not mentally ill. Here, in 153 participants, we investigate brain structural markers that predict the occurrence of hallucinations by comparing patients with schizophrenia who have experienced hallucinations against patients who have not, matched on a number of demographic and clinical variables. Using both newly validated visual classification techniques and automated, data-driven methods, hallucinations were associated with specific brain morphology differences in the paracingulate sulcus, a fold in the medial prefrontal cortex, with a 1cm reduction in sulcal length increasing the likelihood of hallucinations by 19.9\%, regardless of the sensory modality in which they were experienced. The findings suggest a specific morphological basis for a pervasive feature of typical and atypical human experience.",

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AU - Garrison, Jane R.

AU - Fernyhough, Charles

AU - McCarthy-Jones, Simon

AU - Haggard, Mark

AU - Carr, Vaughan

AU - Schall, Ulrich

AU - Scott, Rodney

AU - Jablensky, Assen

AU - Mowry, Bryan

AU - Michie, Patricia

AU - Catts, Stanley

AU - Henskens, Frans

AU - Pantelis, Christos

AU - Loughland, Carmel

AU - Simons, Jon S.

N1 - Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2015/11/17

Y1 - 2015/11/17

N2 - Hallucinations are common in psychiatric disorders, and are also experienced by many individuals who are not mentally ill. Here, in 153 participants, we investigate brain structural markers that predict the occurrence of hallucinations by comparing patients with schizophrenia who have experienced hallucinations against patients who have not, matched on a number of demographic and clinical variables. Using both newly validated visual classification techniques and automated, data-driven methods, hallucinations were associated with specific brain morphology differences in the paracingulate sulcus, a fold in the medial prefrontal cortex, with a 1cm reduction in sulcal length increasing the likelihood of hallucinations by 19.9%, regardless of the sensory modality in which they were experienced. The findings suggest a specific morphological basis for a pervasive feature of typical and atypical human experience.

AB - Hallucinations are common in psychiatric disorders, and are also experienced by many individuals who are not mentally ill. Here, in 153 participants, we investigate brain structural markers that predict the occurrence of hallucinations by comparing patients with schizophrenia who have experienced hallucinations against patients who have not, matched on a number of demographic and clinical variables. Using both newly validated visual classification techniques and automated, data-driven methods, hallucinations were associated with specific brain morphology differences in the paracingulate sulcus, a fold in the medial prefrontal cortex, with a 1cm reduction in sulcal length increasing the likelihood of hallucinations by 19.9%, regardless of the sensory modality in which they were experienced. The findings suggest a specific morphological basis for a pervasive feature of typical and atypical human experience.

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JF - Nature Communications

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ER -

Paracingulate sulcus morphology is associated with hallucinations in the human brain

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