Parental sex effects in bipolar affective disorder pedigrees

J. A. Donald; J. A. Salmon; L. J. Adams; T. Littlejohn; A. Maher; P. B. Mitchell; P. R. Schofield

doi:10.1002/(SICI)1098-2272(1997)14:6<611::AID-GEPI10>3.0.CO;2-T

Parental sex effects in bipolar affective disorder pedigrees

J. A. Donald^*, J. A. Salmon, L. J. Adams, T. Littlejohn, A. Maher, P. B. Mitchell, P. R. Schofield

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

A combined linkage analysis was performed on chromosome 18 data and produced modest evidence in three of four data sets for linkage of a susceptibility locus for bipolar disorder to markers on chromosome 18p. All data sets showed a preponderance of females among affected individuals. When this was taken into account, no convincing evidence was obtained for excess transmission from mothers compared to fathers. In addition, there was no evidence for differences in the proportions of affected offspring from affected fathers and mothers. We conclude that these combined data do not support previous suggestions of a maternal effect on transmission of bipolar affective disorder.

Original language	English
Pages (from-to)	611-616
Number of pages	6
Journal	Genetic Epidemiology
Volume	14
Issue number	6
DOIs	https://doi.org/10.1002/(SICI)1098-2272(1997)14:6<611::AID-GEPI10>3.0.CO;2-T
Publication status	Published - 1997

Keywords

linkage analysis
manic-depressive illness
maternal transmission

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10.1002/(SICI)1098-2272(1997)14:6<611::AID-GEPI10>3.0.CO;2-T

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title = "Parental sex effects in bipolar affective disorder pedigrees",

abstract = "A combined linkage analysis was performed on chromosome 18 data and produced modest evidence in three of four data sets for linkage of a susceptibility locus for bipolar disorder to markers on chromosome 18p. All data sets showed a preponderance of females among affected individuals. When this was taken into account, no convincing evidence was obtained for excess transmission from mothers compared to fathers. In addition, there was no evidence for differences in the proportions of affected offspring from affected fathers and mothers. We conclude that these combined data do not support previous suggestions of a maternal effect on transmission of bipolar affective disorder.",

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T1 - Parental sex effects in bipolar affective disorder pedigrees

AU - Donald, J. A.

AU - Salmon, J. A.

AU - Adams, L. J.

AU - Littlejohn, T.

AU - Maher, A.

AU - Mitchell, P. B.

AU - Schofield, P. R.

PY - 1997

Y1 - 1997

N2 - A combined linkage analysis was performed on chromosome 18 data and produced modest evidence in three of four data sets for linkage of a susceptibility locus for bipolar disorder to markers on chromosome 18p. All data sets showed a preponderance of females among affected individuals. When this was taken into account, no convincing evidence was obtained for excess transmission from mothers compared to fathers. In addition, there was no evidence for differences in the proportions of affected offspring from affected fathers and mothers. We conclude that these combined data do not support previous suggestions of a maternal effect on transmission of bipolar affective disorder.

AB - A combined linkage analysis was performed on chromosome 18 data and produced modest evidence in three of four data sets for linkage of a susceptibility locus for bipolar disorder to markers on chromosome 18p. All data sets showed a preponderance of females among affected individuals. When this was taken into account, no convincing evidence was obtained for excess transmission from mothers compared to fathers. In addition, there was no evidence for differences in the proportions of affected offspring from affected fathers and mothers. We conclude that these combined data do not support previous suggestions of a maternal effect on transmission of bipolar affective disorder.

KW - linkage analysis

KW - manic-depressive illness

KW - maternal transmission

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C2 - 9433551

AN - SCOPUS:0031442933

SN - 0741-0395

VL - 14

SP - 611

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JO - Genetic Epidemiology

JF - Genetic Epidemiology

IS - 6

ER -

Parental sex effects in bipolar affective disorder pedigrees

Abstract

Keywords

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