Partial Volume Correction in SPECT Using Anatomical Information and Iterative FBP

Kjell Erlandsson*, Brian F. Hutton

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    6 Citations (Scopus)


    The ability to correctly quantify activity concentration with single photon emission computed tomography (SPECT) is limited by its spatial resolution. Blurring of data between adjacent structures, which is known as partial volume effects, can be compensated for by utilizing high resolution structural information from other imaging modalities such as CT or MRI. Previously developed partial volume correction (PVC) methods normally assume a spatially invariant point spread function. In SPECT this is not a good approximation, since the resolution varies with the distance from the collimator. A new method, p-PVC, was developed in this paper, which takes into account the distance dependent blurring. The method operates in projection space and is combined with filtered back-projection (FBP) reconstruction. Results from simulations show that similar quantitative results could be obtained with p-PVC+FBP as with OSEM with resolution recovery, although with better structural definition and an order of magnitude faster.

    Original languageEnglish
    Pages (from-to)50-55
    Number of pages6
    JournalTsinghua Science and Technology
    Issue number1
    Publication statusPublished - Feb 2010


    • partial volume correction (PVC)
    • partial volume effect (PVE)
    • SPECT


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