TY - JOUR
T1 - Patent foramen ovale and obstructive sleep apnea
T2 - a new association?
AU - Lau, Edmund M. T.
AU - Yee, Brendon J.
AU - Grunstein, Ronald R.
AU - Celermajer, David S.
PY - 2010/12
Y1 - 2010/12
N2 - Patent foramen ovale (PFO) is a common congenital cardiac defect of the atrial septal wall affecting up to 25% of the population. PFO has received much clinical interest because it has been implicated in disease states such as stroke, migraine and decompression illness. More recently, there has been emerging evidence to support a clinically important relationship between PFO and obstructive sleep apnea (OSA). Furthermore, minimally invasive percutaneous techniques are now available for closure of PFO. We will review the current state of knowledge in the relationship between PFO and OSA, with emphasis on the pathophysiological interactions and clinical implications of this association.
AB - Patent foramen ovale (PFO) is a common congenital cardiac defect of the atrial septal wall affecting up to 25% of the population. PFO has received much clinical interest because it has been implicated in disease states such as stroke, migraine and decompression illness. More recently, there has been emerging evidence to support a clinically important relationship between PFO and obstructive sleep apnea (OSA). Furthermore, minimally invasive percutaneous techniques are now available for closure of PFO. We will review the current state of knowledge in the relationship between PFO and OSA, with emphasis on the pathophysiological interactions and clinical implications of this association.
KW - Hypoxemia
KW - Intracardiac shunting
KW - Obstructive sleep apnea
KW - Patent foramen ovale
UR - http://www.scopus.com/inward/record.url?scp=77957865969&partnerID=8YFLogxK
U2 - 10.1016/j.smrv.2010.02.002
DO - 10.1016/j.smrv.2010.02.002
M3 - Review article
C2 - 20451427
AN - SCOPUS:77957865969
SN - 1087-0792
VL - 14
SP - 391
EP - 395
JO - Sleep Medicine Reviews
JF - Sleep Medicine Reviews
IS - 6
ER -