Pathological complete response in malignant pleural mesothelioma patients following induction chemotherapy

predictive factors and outcomes

Brandon Lau, Sanjeev Kumar, Tristan Yan, Juliet Burn, Catherine Kennedy, Jocelyn McLean, Michael Boyer, Brian McCaughan, Steven Kao*

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A small proportion of patients with malignant pleural mesothelioma (MPM) achieve pathological complete response (CR) following treatment with current practice induction chemotherapy. Our analysis of 58 patients with MPM treated with platinum-based chemotherapy showed 4 patients (7%) attained pathological CR at subsequent extrapleural pneumonectomy (EPP). Patient and tumour factors such as age, gender, smoking habit, histological subtype, and clinical stage were not found to be associated with pathological CR. Patients with pathological CR had longer disease-free survival (29.2 vs. 13.8 months; p = 0.08) and overall survival (76.4 vs. 23.4 months; p = 0.06) but this did not reach statistical significance. Our study suggests that patients who achieve pathological CR after chemotherapy may have improved survival in MPM.

Original languageEnglish
Pages (from-to)75-78
Number of pages4
JournalLung Cancer
Volume111
DOIs
Publication statusPublished - Sep 2017
Externally publishedYes

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Keywords

  • extrapleural pneumonectomy
  • malignant pleural mesothelioma
  • pathological response
  • prognosis
  • survival

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