TY - JOUR
T1 - Pathological complete response in malignant pleural mesothelioma patients following induction chemotherapy
T2 - predictive factors and outcomes
AU - Lau, Brandon
AU - Kumar, Sanjeev
AU - Yan, Tristan
AU - Burn, Juliet
AU - Kennedy, Catherine
AU - McLean, Jocelyn
AU - Boyer, Michael
AU - McCaughan, Brian
AU - Kao, Steven
PY - 2017/9
Y1 - 2017/9
N2 - A small proportion of patients with malignant pleural mesothelioma (MPM) achieve pathological complete response (CR) following treatment with current practice induction chemotherapy. Our analysis of 58 patients with MPM treated with platinum-based chemotherapy showed 4 patients (7%) attained pathological CR at subsequent extrapleural pneumonectomy (EPP). Patient and tumour factors such as age, gender, smoking habit, histological subtype, and clinical stage were not found to be associated with pathological CR. Patients with pathological CR had longer disease-free survival (29.2 vs. 13.8 months; p = 0.08) and overall survival (76.4 vs. 23.4 months; p = 0.06) but this did not reach statistical significance. Our study suggests that patients who achieve pathological CR after chemotherapy may have improved survival in MPM.
AB - A small proportion of patients with malignant pleural mesothelioma (MPM) achieve pathological complete response (CR) following treatment with current practice induction chemotherapy. Our analysis of 58 patients with MPM treated with platinum-based chemotherapy showed 4 patients (7%) attained pathological CR at subsequent extrapleural pneumonectomy (EPP). Patient and tumour factors such as age, gender, smoking habit, histological subtype, and clinical stage were not found to be associated with pathological CR. Patients with pathological CR had longer disease-free survival (29.2 vs. 13.8 months; p = 0.08) and overall survival (76.4 vs. 23.4 months; p = 0.06) but this did not reach statistical significance. Our study suggests that patients who achieve pathological CR after chemotherapy may have improved survival in MPM.
KW - extrapleural pneumonectomy
KW - malignant pleural mesothelioma
KW - pathological response
KW - prognosis
KW - survival
UR - http://www.scopus.com/inward/record.url?scp=85024931814&partnerID=8YFLogxK
U2 - 10.1016/j.lungcan.2017.07.010
DO - 10.1016/j.lungcan.2017.07.010
M3 - Article
C2 - 28838403
AN - SCOPUS:85024931814
SN - 0169-5002
VL - 111
SP - 75
EP - 78
JO - Lung Cancer
JF - Lung Cancer
ER -