Pathological complete response in malignant pleural mesothelioma patients following induction chemotherapy: predictive factors and outcomes

Brandon Lau; Sanjeev Kumar; Tristan Yan; Juliet Burn; Catherine Kennedy; Jocelyn McLean; Michael Boyer; Brian McCaughan; Steven Kao

doi:10.1016/j.lungcan.2017.07.010

Pathological complete response in malignant pleural mesothelioma patients following induction chemotherapy: predictive factors and outcomes

Brandon Lau, Sanjeev Kumar, Tristan Yan, Juliet Burn, Catherine Kennedy, Jocelyn McLean, Michael Boyer, Brian McCaughan, Steven Kao^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

A small proportion of patients with malignant pleural mesothelioma (MPM) achieve pathological complete response (CR) following treatment with current practice induction chemotherapy. Our analysis of 58 patients with MPM treated with platinum-based chemotherapy showed 4 patients (7%) attained pathological CR at subsequent extrapleural pneumonectomy (EPP). Patient and tumour factors such as age, gender, smoking habit, histological subtype, and clinical stage were not found to be associated with pathological CR. Patients with pathological CR had longer disease-free survival (29.2 vs. 13.8 months; p = 0.08) and overall survival (76.4 vs. 23.4 months; p = 0.06) but this did not reach statistical significance. Our study suggests that patients who achieve pathological CR after chemotherapy may have improved survival in MPM.

Original language	English
Pages (from-to)	75-78
Number of pages	4
Journal	Lung Cancer
Volume	111
DOIs	https://doi.org/10.1016/j.lungcan.2017.07.010
Publication status	Published - Sept 2017
Externally published	Yes

Keywords

extrapleural pneumonectomy
malignant pleural mesothelioma
pathological response
prognosis
survival

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10.1016/j.lungcan.2017.07.010

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@article{320011e2122047059a0afe7d1ada37dd,

title = "Pathological complete response in malignant pleural mesothelioma patients following induction chemotherapy: predictive factors and outcomes",

abstract = "A small proportion of patients with malignant pleural mesothelioma (MPM) achieve pathological complete response (CR) following treatment with current practice induction chemotherapy. Our analysis of 58 patients with MPM treated with platinum-based chemotherapy showed 4 patients (7\%) attained pathological CR at subsequent extrapleural pneumonectomy (EPP). Patient and tumour factors such as age, gender, smoking habit, histological subtype, and clinical stage were not found to be associated with pathological CR. Patients with pathological CR had longer disease-free survival (29.2 vs. 13.8 months; p = 0.08) and overall survival (76.4 vs. 23.4 months; p = 0.06) but this did not reach statistical significance. Our study suggests that patients who achieve pathological CR after chemotherapy may have improved survival in MPM.",

keywords = "extrapleural pneumonectomy, malignant pleural mesothelioma, pathological response, prognosis, survival",

author = "Brandon Lau and Sanjeev Kumar and Tristan Yan and Juliet Burn and Catherine Kennedy and Jocelyn McLean and Michael Boyer and Brian McCaughan and Steven Kao",

year = "2017",

month = sep,

doi = "10.1016/j.lungcan.2017.07.010",

language = "English",

volume = "111",

pages = "75--78",

journal = "Lung Cancer",

issn = "0169-5002",

publisher = "Elsevier",

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TY - JOUR

T1 - Pathological complete response in malignant pleural mesothelioma patients following induction chemotherapy

T2 - predictive factors and outcomes

AU - Lau, Brandon

AU - Kumar, Sanjeev

AU - Yan, Tristan

AU - Burn, Juliet

AU - Kennedy, Catherine

AU - McLean, Jocelyn

AU - Boyer, Michael

AU - McCaughan, Brian

AU - Kao, Steven

PY - 2017/9

Y1 - 2017/9

N2 - A small proportion of patients with malignant pleural mesothelioma (MPM) achieve pathological complete response (CR) following treatment with current practice induction chemotherapy. Our analysis of 58 patients with MPM treated with platinum-based chemotherapy showed 4 patients (7%) attained pathological CR at subsequent extrapleural pneumonectomy (EPP). Patient and tumour factors such as age, gender, smoking habit, histological subtype, and clinical stage were not found to be associated with pathological CR. Patients with pathological CR had longer disease-free survival (29.2 vs. 13.8 months; p = 0.08) and overall survival (76.4 vs. 23.4 months; p = 0.06) but this did not reach statistical significance. Our study suggests that patients who achieve pathological CR after chemotherapy may have improved survival in MPM.

AB - A small proportion of patients with malignant pleural mesothelioma (MPM) achieve pathological complete response (CR) following treatment with current practice induction chemotherapy. Our analysis of 58 patients with MPM treated with platinum-based chemotherapy showed 4 patients (7%) attained pathological CR at subsequent extrapleural pneumonectomy (EPP). Patient and tumour factors such as age, gender, smoking habit, histological subtype, and clinical stage were not found to be associated with pathological CR. Patients with pathological CR had longer disease-free survival (29.2 vs. 13.8 months; p = 0.08) and overall survival (76.4 vs. 23.4 months; p = 0.06) but this did not reach statistical significance. Our study suggests that patients who achieve pathological CR after chemotherapy may have improved survival in MPM.

KW - extrapleural pneumonectomy

KW - malignant pleural mesothelioma

KW - pathological response

KW - prognosis

KW - survival

UR - https://www.scopus.com/pages/publications/85024931814

U2 - 10.1016/j.lungcan.2017.07.010

DO - 10.1016/j.lungcan.2017.07.010

M3 - Article

C2 - 28838403

AN - SCOPUS:85024931814

SN - 0169-5002

VL - 111

SP - 75

EP - 78

JO - Lung Cancer

JF - Lung Cancer

ER -

Pathological complete response in malignant pleural mesothelioma patients following induction chemotherapy: predictive factors and outcomes

Abstract

Keywords

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