Pathology of behavior in PD: what is known and what is not?

Kaylena A. Ehgoetz Martens; Simon J. G. Lewis

doi:10.1016/j.jns.2016.12.062

Pathology of behavior in PD: what is known and what is not?

Kaylena A. Ehgoetz Martens^*, Simon J. G. Lewis

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

29 Citations (Scopus)

18 Downloads (Pure)

Abstract

Abnormal behavior in Parkinson's disease (PD) stems from a complex orchestration of impaired neural networks that result from PD-related neurodegeneration across multiple levels. Typically, cellular and tissue abnormalities generate neurochemical changes and disrupt specific regions of the brain, in turn creating impaired neural circuits and dysfunctional global networks. The objective of this chapter is to provide an overview of the array of pathological changes that have been linked to different behavioral symptoms of PD such as depression, anxiety, apathy, fatigue, impulse control disorders, psychosis, sleep disorders and dementia.

Original language	English
Pages (from-to)	9-16
Number of pages	8
Journal	Journal of the Neurological Sciences
Volume	374
DOIs	https://doi.org/10.1016/j.jns.2016.12.062
Publication status	Published - 15 Mar 2017
Externally published	Yes

Bibliographical note

Copyright the Author(s) 2017. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

Anxiety
Apathy
Dementia
Depression
Fatigue
Hallucinations
Impulse control disorders
Neuropsychiatric
Parkinson's disease
Pathology
Psychosis
Sleep

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10.1016/j.jns.2016.12.062Licence: CC BY-NC-ND

Publisher version (open access)Final published version, 380 KBLicence: CC BY-NC-ND

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title = "Pathology of behavior in PD: what is known and what is not?",

abstract = "Abnormal behavior in Parkinson's disease (PD) stems from a complex orchestration of impaired neural networks that result from PD-related neurodegeneration across multiple levels. Typically, cellular and tissue abnormalities generate neurochemical changes and disrupt specific regions of the brain, in turn creating impaired neural circuits and dysfunctional global networks. The objective of this chapter is to provide an overview of the array of pathological changes that have been linked to different behavioral symptoms of PD such as depression, anxiety, apathy, fatigue, impulse control disorders, psychosis, sleep disorders and dementia.",

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T2 - what is known and what is not?

AU - Ehgoetz Martens, Kaylena A.

AU - Lewis, Simon J. G.

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Y1 - 2017/3/15

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AB - Abnormal behavior in Parkinson's disease (PD) stems from a complex orchestration of impaired neural networks that result from PD-related neurodegeneration across multiple levels. Typically, cellular and tissue abnormalities generate neurochemical changes and disrupt specific regions of the brain, in turn creating impaired neural circuits and dysfunctional global networks. The objective of this chapter is to provide an overview of the array of pathological changes that have been linked to different behavioral symptoms of PD such as depression, anxiety, apathy, fatigue, impulse control disorders, psychosis, sleep disorders and dementia.

KW - Anxiety

KW - Apathy

KW - Dementia

KW - Depression

KW - Fatigue

KW - Hallucinations

KW - Impulse control disorders

KW - Neuropsychiatric

KW - Parkinson's disease

KW - Pathology

KW - Psychosis

KW - Sleep

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EP - 16

JO - Journal of the Neurological Sciences

JF - Journal of the Neurological Sciences

ER -

Pathology of behavior in PD: what is known and what is not?

Abstract

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Keywords

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