TY - JOUR
T1 - Pathophysiological pathway differences in children who present with COVID-19 ARDS compared to COVID -19 induced MIS-C
AU - McCafferty, Conor
AU - Cai, Tengyi
AU - Borgel, Delphine
AU - Lasne, Dominique
AU - Renolleau, Sylvain
AU - Vedrenne-Cloquet, Meryl
AU - Bonnet, Damien
AU - Wu, Jemma
AU - Zaw, Thiri
AU - Bhatnagar, Atul
AU - Song, Xiaomin
AU - Van Den Helm, Suelyn
AU - Letunica, Natasha
AU - Attard, Chantal
AU - Karlaftis, Vasiliki
AU - Praporski, Slavica
AU - Ignjatovic, Vera
AU - Monagle, Paul
N1 - Copyright the Author(s) 2022. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.
PY - 2022/5/2
Y1 - 2022/5/2
N2 - COVID-19 has infected more than 275 million worldwide (at the beginning of 2022). Children appear less susceptible to COVID-19 and present with milder symptoms. Cases of children with COVID-19 developing clinical features of Kawasaki-disease have been described. Here we utilise Mass Spectrometry proteomics to determine the plasma proteins expressed in healthy children pre-pandemic, children with multisystem inflammatory syndrome (MIS-C) and children with COVID-19 induced ARDS. Pathway analyses were performed to determine the affected pathways. 76 proteins are differentially expressed across the groups, with 85 and 52 proteins specific to MIS-C and COVID-19 ARDS, respectively. Complement and coagulation activation are implicated in these clinical phenotypes, however there was significant contribution of FcGR and BCR activation in MIS-C and scavenging of haem and retinoid metabolism in COVID-19 ARDS. We show global proteomic differences in MIS-C and COVID-ARDS, although both show complement and coagulation dysregulation. The results contribute to our understanding of MIS-C and COVID-19 ARDS in children.
AB - COVID-19 has infected more than 275 million worldwide (at the beginning of 2022). Children appear less susceptible to COVID-19 and present with milder symptoms. Cases of children with COVID-19 developing clinical features of Kawasaki-disease have been described. Here we utilise Mass Spectrometry proteomics to determine the plasma proteins expressed in healthy children pre-pandemic, children with multisystem inflammatory syndrome (MIS-C) and children with COVID-19 induced ARDS. Pathway analyses were performed to determine the affected pathways. 76 proteins are differentially expressed across the groups, with 85 and 52 proteins specific to MIS-C and COVID-19 ARDS, respectively. Complement and coagulation activation are implicated in these clinical phenotypes, however there was significant contribution of FcGR and BCR activation in MIS-C and scavenging of haem and retinoid metabolism in COVID-19 ARDS. We show global proteomic differences in MIS-C and COVID-ARDS, although both show complement and coagulation dysregulation. The results contribute to our understanding of MIS-C and COVID-19 ARDS in children.
UR - http://www.scopus.com/inward/record.url?scp=85129258021&partnerID=8YFLogxK
U2 - 10.1038/s41467-022-29951-9
DO - 10.1038/s41467-022-29951-9
M3 - Article
C2 - 35501302
AN - SCOPUS:85129258021
SN - 2041-1723
VL - 13
SP - 1
EP - 8
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 2391
ER -