Pathophysiology and animal modeling of underactive bladder

Pradeep Tyagi, Phillip P. Smith, George A. Kuchel, William C. de Groat, Lori A. Birder, Christopher J. Chermansky, Rosalyn M. Adam, Vincent Tse, Michael B. Chancellor*, Naoki Yoshimura

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

47 Citations (Scopus)


While the symptomology of underactive bladder (UAB) may imply a primary dysfunction of the detrusor muscle, insights into pathophysiology indicate that both myogenic and neurogenic mechanisms need to be considered. Due to lack of proper animal models, the current understanding of the UAB pathophysiology is limited, and much of what is known about the clinical etiology of the condition has been derived from epidemiological data. We hereby review current state of the art in the understanding of the pathophysiology of and animal models used to study the UAB.

Original languageEnglish
Pages (from-to)S11-S21
Number of pages11
JournalInternational Urology and Nephrology
Issue number1
Publication statusPublished - Sept 2014
Externally publishedYes


  • animal model
  • detrusor
  • surrogate
  • underactivity


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