Pathways of Pb and Mn observed in a 5-year longitudinal investigation in young children and environmental measures from an urban setting

Brian Gulson; Karen Mizon; Alan Taylor; Michael Korsch; J. Michael Davis; Honway Louie; Michael Wu; Laura Gomez; Luminita Antin

doi:10.1016/j.envpol.2014.04.009

Pathways of Pb and Mn observed in a 5-year longitudinal investigation in young children and environmental measures from an urban setting

Brian Gulson^*, Karen Mizon, Alan Taylor, Michael Korsch, J. Michael Davis, Honway Louie, Michael Wu, Laura Gomez, Luminita Antin

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

We monitored 108 children ≤5 years on a 6-month basis for up to 5 years in a major urban setting. Samples (n ∼ 7000) included blood, urine, handwipes (interior, and after exterior playing), 6-day duplicate diet, drinking water, interior house and day care dust-fall accumulation using petri dishes, exterior dust-fall accumulation, exterior dust sweepings, paint, soil and urban air. The geometric mean blood Pb (PbB) was 2.1 μg/dL and blood Mn (MnB) was 10.0 μg/L. Following a path modelling approach, mixed model analyses for a fully adjusted model showed the strongest associations for PbB were with interior house dust and soil; for MnB there were no significant associations with any predictors. Predictor variables only explained 9% of the variance for Pb and 0.7% for Mn. Relationships between environmental measures and PbB in children are not straightforward; soil and dust sweepings contribute only about 1/5th of the amounts to PbB found in other studies.

Original language	English
Pages (from-to)	38-49
Number of pages	12
Journal	Environmental Pollution
Volume	191
DOIs	https://doi.org/10.1016/j.envpol.2014.04.009
Publication status	Published - 2014

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title = "Pathways of Pb and Mn observed in a 5-year longitudinal investigation in young children and environmental measures from an urban setting",

abstract = "We monitored 108 children ≤5 years on a 6-month basis for up to 5 years in a major urban setting. Samples (n ∼ 7000) included blood, urine, handwipes (interior, and after exterior playing), 6-day duplicate diet, drinking water, interior house and day care dust-fall accumulation using petri dishes, exterior dust-fall accumulation, exterior dust sweepings, paint, soil and urban air. The geometric mean blood Pb (PbB) was 2.1 μg/dL and blood Mn (MnB) was 10.0 μg/L. Following a path modelling approach, mixed model analyses for a fully adjusted model showed the strongest associations for PbB were with interior house dust and soil; for MnB there were no significant associations with any predictors. Predictor variables only explained 9% of the variance for Pb and 0.7% for Mn. Relationships between environmental measures and PbB in children are not straightforward; soil and dust sweepings contribute only about 1/5th of the amounts to PbB found in other studies.",

author = "Brian Gulson and Karen Mizon and Alan Taylor and Michael Korsch and Davis, {J. Michael} and Honway Louie and Michael Wu and Laura Gomez and Luminita Antin",

year = "2014",

doi = "10.1016/j.envpol.2014.04.009",

language = "English",

volume = "191",

pages = "38--49",

journal = "Environmental Pollution",

issn = "0269-7491",

publisher = "Elsevier",

}

Pathways of Pb and Mn observed in a 5-year longitudinal investigation in young children and environmental measures from an urban setting. / Gulson, Brian; Mizon, Karen; Taylor, Alan; Korsch, Michael; Davis, J. Michael; Louie, Honway; Wu, Michael; Gomez, Laura; Antin, Luminita.

In: Environmental Pollution, Vol. 191, 2014, p. 38-49.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

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AU - Gulson, Brian

AU - Mizon, Karen

AU - Taylor, Alan

AU - Korsch, Michael

AU - Davis, J. Michael

AU - Louie, Honway

AU - Wu, Michael

AU - Gomez, Laura

AU - Antin, Luminita

PY - 2014

Y1 - 2014

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AB - We monitored 108 children ≤5 years on a 6-month basis for up to 5 years in a major urban setting. Samples (n ∼ 7000) included blood, urine, handwipes (interior, and after exterior playing), 6-day duplicate diet, drinking water, interior house and day care dust-fall accumulation using petri dishes, exterior dust-fall accumulation, exterior dust sweepings, paint, soil and urban air. The geometric mean blood Pb (PbB) was 2.1 μg/dL and blood Mn (MnB) was 10.0 μg/L. Following a path modelling approach, mixed model analyses for a fully adjusted model showed the strongest associations for PbB were with interior house dust and soil; for MnB there were no significant associations with any predictors. Predictor variables only explained 9% of the variance for Pb and 0.7% for Mn. Relationships between environmental measures and PbB in children are not straightforward; soil and dust sweepings contribute only about 1/5th of the amounts to PbB found in other studies.

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