Pattern electroretinograms from hemifields in normal subjects and patients with glaucoma

S. L. Graham*, V. A T Wong, S. M. Drance, F. S. Mikelberg

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)

Abstract

Purpose. Because glaucomatous visual field loss predominantly occurs in one hemifield, a baseline ratio of pattern electroretinogram (PERG) hemifield amplitudes (upper field:lower field) was determined in normal subjects and then examined in patients with glaucoma. Methods. In 26 normal subjects and eight patients with glaucoma with typical arcuate field loss involving the test area (central 20°), hemifield PERGs were recorded using checkerboard screens of check size 0.5° and frequency 3.75 reversals per second (transient) and 15 reversals per second (steady state). Results. The ratios obtained for normal central upper:lower amplitudes were 0.95 ± 0.13 (transient) and 0.93 ± 0.10 (steady state Fourier second harmonic). Wide nasal-field (52° x 42°) PERG ratios recorded on two subjects confirmed that the ratio held across large retinal areas. The ratio did not change with age or check size. The ratio showed less variability between patients than PERG amplitudes. In the patients with glaucoma, the hemifield PERG amplitude correlated with summed visual field thresholds for that area. Patients with glaucoma could be discriminated from normals by an abnormal ratio (>2 SD) in seven of the eight patients. In two additional patients with more peripheral scotomas, the ratio remained normal. Conclusions. In normals, the upper:lower hemifield PERG ratio is slightly <1.0 and remains stable with age. In glaucoma, visual field defects are associated with PERG reductions in the corresponding hemifield. An abnormal PERG hemifield ratio can be found in many patients, although more peripheral and symmetrical losses may still be missed.

Original languageEnglish
Pages (from-to)3347-3356
Number of pages10
JournalInvestigative Ophthalmology and Visual Science
Volume35
Issue number9
Publication statusPublished - 1994
Externally publishedYes

Keywords

  • aging
  • electroretinogram
  • glaucoma
  • normal distribution
  • pattern recognition
  • visual

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