Patterns and trends in the incidence of paediatric and adult germ cell tumours in Australia, 1982-2011

Marina T. van Leeuwen, Howard Gurney, Jennifer J. Turner, Sandra L. Turner, Sallie Anne Pearson, Maarit A. Laaksonen, Paul Harnett, Bavanthi Balakrishnar, Dhanusha Sabanathan, Claire M. Vajdic

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Purpose: Germ cell tumour (GCT) aetiology is uncertain and comprehensive epidemiological studies of GCT incidence are few. 

Methods: Nationwide data on all malignant GCTs notified to Australian population-based cancer registries during 1982–2011 were obtained. Age- and sex-specific, and World age-standardised incidence rates were calculated for paediatric (0–14) and adult (15+) cases using the latest WHO subtype classification scheme. Temporal trends were examined using Joinpoint regression. 

Results: There were 17,279 GCTs (552 paediatric, 16,727 adult). Age-specific incidence in males (all histologies combined) was bimodal, with peaks during infancy for most sites, and second, larger, peaks during young adulthood. Incidence of ovarian tumours peaked at age 15–19. Around half of paediatric tumours were extragonadal, whereas adult tumours were mostly gonadal. Yolk sac tumours and teratomas predominated in infants, whereas germinomas became more frequent towards adulthood. Increasing incidence trends for some adult gonadal tumours have stabilised; the trend for male extragonadal tumours is also declining. 

Conclusion: Broad similarities in the shape of age-specific incidence curves, particularly for gonadal, central nervous system, and mediastinal tumours provide epidemiological support for commonalities in aetiology among clinically disparate GCT subtypes. Differences in peak ages reflect underlying subtype-specific biological differences. Declining incidence trends for some adult gonadal tumours accords with the global transition in GCT incidence, and supports the possibility of a reduction in prevalence of shared aetiological exposures.

LanguageEnglish
Pages15-21
Number of pages7
JournalCancer Epidemiology
Volume43
DOIs
Publication statusPublished - 1 Aug 2016

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Germ Cell and Embryonal Neoplasms
Pediatrics
Incidence
Neoplasms
Germinoma
Endodermal Sinus Tumor
Central Nervous System Neoplasms
Teratoma
Registries
Epidemiologic Studies
Histology
Population

Keywords

  • Germ cell neoplasms
  • Testicular neoplasms
  • Ovarian neoplasms
  • Incidence
  • Australia

Cite this

van Leeuwen, M. T., Gurney, H., Turner, J. J., Turner, S. L., Pearson, S. A., Laaksonen, M. A., ... Vajdic, C. M. (2016). Patterns and trends in the incidence of paediatric and adult germ cell tumours in Australia, 1982-2011. Cancer Epidemiology, 43, 15-21. https://doi.org/10.1016/j.canep.2016.05.006
van Leeuwen, Marina T. ; Gurney, Howard ; Turner, Jennifer J. ; Turner, Sandra L. ; Pearson, Sallie Anne ; Laaksonen, Maarit A. ; Harnett, Paul ; Balakrishnar, Bavanthi ; Sabanathan, Dhanusha ; Vajdic, Claire M. / Patterns and trends in the incidence of paediatric and adult germ cell tumours in Australia, 1982-2011. In: Cancer Epidemiology. 2016 ; Vol. 43. pp. 15-21.
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abstract = "Purpose: Germ cell tumour (GCT) aetiology is uncertain and comprehensive epidemiological studies of GCT incidence are few. Methods: Nationwide data on all malignant GCTs notified to Australian population-based cancer registries during 1982–2011 were obtained. Age- and sex-specific, and World age-standardised incidence rates were calculated for paediatric (0–14) and adult (15+) cases using the latest WHO subtype classification scheme. Temporal trends were examined using Joinpoint regression. Results: There were 17,279 GCTs (552 paediatric, 16,727 adult). Age-specific incidence in males (all histologies combined) was bimodal, with peaks during infancy for most sites, and second, larger, peaks during young adulthood. Incidence of ovarian tumours peaked at age 15–19. Around half of paediatric tumours were extragonadal, whereas adult tumours were mostly gonadal. Yolk sac tumours and teratomas predominated in infants, whereas germinomas became more frequent towards adulthood. Increasing incidence trends for some adult gonadal tumours have stabilised; the trend for male extragonadal tumours is also declining. Conclusion: Broad similarities in the shape of age-specific incidence curves, particularly for gonadal, central nervous system, and mediastinal tumours provide epidemiological support for commonalities in aetiology among clinically disparate GCT subtypes. Differences in peak ages reflect underlying subtype-specific biological differences. Declining incidence trends for some adult gonadal tumours accords with the global transition in GCT incidence, and supports the possibility of a reduction in prevalence of shared aetiological exposures.",
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van Leeuwen, MT, Gurney, H, Turner, JJ, Turner, SL, Pearson, SA, Laaksonen, MA, Harnett, P, Balakrishnar, B, Sabanathan, D & Vajdic, CM 2016, 'Patterns and trends in the incidence of paediatric and adult germ cell tumours in Australia, 1982-2011', Cancer Epidemiology, vol. 43, pp. 15-21. https://doi.org/10.1016/j.canep.2016.05.006

Patterns and trends in the incidence of paediatric and adult germ cell tumours in Australia, 1982-2011. / van Leeuwen, Marina T.; Gurney, Howard; Turner, Jennifer J.; Turner, Sandra L.; Pearson, Sallie Anne; Laaksonen, Maarit A.; Harnett, Paul; Balakrishnar, Bavanthi; Sabanathan, Dhanusha; Vajdic, Claire M.

In: Cancer Epidemiology, Vol. 43, 01.08.2016, p. 15-21.

Research output: Contribution to journalArticleResearchpeer-review

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AU - van Leeuwen, Marina T.

AU - Gurney, Howard

AU - Turner, Jennifer J.

AU - Turner, Sandra L.

AU - Pearson, Sallie Anne

AU - Laaksonen, Maarit A.

AU - Harnett, Paul

AU - Balakrishnar, Bavanthi

AU - Sabanathan, Dhanusha

AU - Vajdic, Claire M.

PY - 2016/8/1

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N2 - Purpose: Germ cell tumour (GCT) aetiology is uncertain and comprehensive epidemiological studies of GCT incidence are few. Methods: Nationwide data on all malignant GCTs notified to Australian population-based cancer registries during 1982–2011 were obtained. Age- and sex-specific, and World age-standardised incidence rates were calculated for paediatric (0–14) and adult (15+) cases using the latest WHO subtype classification scheme. Temporal trends were examined using Joinpoint regression. Results: There were 17,279 GCTs (552 paediatric, 16,727 adult). Age-specific incidence in males (all histologies combined) was bimodal, with peaks during infancy for most sites, and second, larger, peaks during young adulthood. Incidence of ovarian tumours peaked at age 15–19. Around half of paediatric tumours were extragonadal, whereas adult tumours were mostly gonadal. Yolk sac tumours and teratomas predominated in infants, whereas germinomas became more frequent towards adulthood. Increasing incidence trends for some adult gonadal tumours have stabilised; the trend for male extragonadal tumours is also declining. Conclusion: Broad similarities in the shape of age-specific incidence curves, particularly for gonadal, central nervous system, and mediastinal tumours provide epidemiological support for commonalities in aetiology among clinically disparate GCT subtypes. Differences in peak ages reflect underlying subtype-specific biological differences. Declining incidence trends for some adult gonadal tumours accords with the global transition in GCT incidence, and supports the possibility of a reduction in prevalence of shared aetiological exposures.

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