Paucimannosidic glycoepitopes inhibit tumorigenic processes in glioblastoma multiforme

Yvonne Becker, Sarah Förster, Gerrit H. Gielen, Ian Loke, Morten Thaysen-Andersen, Christine Laurini, Kristin Wehrand, Torsten Pietsch, Simone Diestel*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)
9 Downloads (Pure)


Glioblastoma multiforme is an aggressive cancer type with poor patient outcomes. Interestingly, we reported previously a novel association between the little studied paucimannosidic N-linked glycoepitope and glioblastoma. Paucimannose has only recently been detected in vertebrates where it exhibits a very restricted tumor-specific expression. Herein, we demonstrate for the first time a very high protein paucimannosylation in human grade IV glioblastoma and U-87MG and U-138MG glioblastoma cells. Furthermore, we revealed the involvement of paucimannosidic epitopes in tumorigenic processes including cell proliferation, migration, invasion and adhesion. Finally, we identified AHNAK which is discussed as a tumor suppressor as the first paucimannose-carrying protein in glioblastoma and show the involvement of AHNAK in the observed paucimannose-dependent effects. This study is the first to provide evidence of a protective role of paucimannosylation in glioblastoma, a relationship that with further in vivo support may have far reaching benefits for patients suffering from this often fatal disease.

Original languageEnglish
Pages (from-to)4449-4465
Number of pages17
Issue number43
Publication statusPublished - 9 Jul 2019

Bibliographical note

Copyright the Author(s). Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.


  • cancer progression
  • glioblastoma multiforme
  • N-glycosylation
  • paucimannosidic epitopes


Dive into the research topics of 'Paucimannosidic glycoepitopes inhibit tumorigenic processes in glioblastoma multiforme'. Together they form a unique fingerprint.

Cite this