PAX3: a molecule with oncogenic or tumor suppressor function is involved in cancer

Ashok Arasu, Sengottuvelan Murugan, Musthafa Mohamed Essa*, Thirunavukkarasu Velusamy, Gilles J. Guillemin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

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Abstract

Metastasis is the most deadly aspect of cancer and results from acquired gene regulation abnormalities in tumor cells. Transcriptional regulation is an essential component of controlling of gene function and its failure could contribute to tumor progression and metastasis. During cancer progression, deregulation of oncogenic or tumor suppressive transcription factors, as well as master cell fate regulators, collectively influences multiple steps of the metastasis cascade, including local invasion and dissemination of the tumor to distant organs. Transcription factor PAX3/Pax3, which contributes to diverse cell lineages during embryonic development, plays a major role in tumorigenesis. Mutations in this gene can cause neurodevelopmental disease and the existing literature supports that there is a potential link between aberrant expression of PAX3 genes in adult tissues and a wide variety of cancers. PAX3 function is tissue-specific and could contribute to tumorigenesis either directly as oncogene or as a tumor suppressor by losing its function. In this review, we discuss comprehensively the differential role played by PAX3 in various tissues and how its aberrant expression is implicated in disease development. This review particularly highlights the oncogenic and tumor suppressor role played by PAX3 in different cancers and underlines the importance of precisely identifying tissue-specific role of PAX3 in order to determine its exact role in development of cancer. 


Corrigendum: In the article titled “PAX3: A Molecule with Oncogenic or Tumor Suppressor Function Is Involved in Cancer” [1], Dr. Mathivanan Jothi was missed in the acknowledgements section. As a former mentor to Ashok Arasu contributing to his concepts, ideas and discussions on which review article is based, the acknowledgements section is updated to reflect this.Acknowledgment The authors acknowledge Dr. Mathivanan Jothi, Department of Human Genetics, National Institute of Mental Health and Neurosciences, Bengaluru, India, a former mentor to Ashok Arasu for his concepts, ideas and discussion which are the basis for this review article. The authors apologize for any inconvenience or misunderstanding.

Original languageEnglish
Article number1095459
Pages (from-to)1-12
Number of pages12
JournalBioMed Research International
Volume2018
DOIs
Publication statusPublished - 16 Aug 2018

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Copyright the Author(s) 2018. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

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