Abstract
Brown adipose tissue (BAT) has been widely reported to affect the efficacy of 18F-FDG PET in oncology. Several small studies have found that warming the patient both before 18F-FDG injection and during the uptake phase can reduce the frequency of BAT uptake. Pharmaceutical approaches such as propranolol and diazepam have also been used. Methods: We describe two case studies that demonstrated the impact of combined patient warming and diazepam administration on BAT uptake in pediatric 18F-FDG PET images. To support these findings, we performed a retrospective analysis of 139 patients: 71 who received warming only and 68 who received warming combined with diazepam. Results: BAT uptake was significantly less frequent in patients who received diazepam (16.2%) than in those who did not (33.8%) (P = 0.0167), particularly in female patients (7.4% vs. 26.7%) (P = 0.0486). Conclusion: Although patient warming alone reduces the frequency of BAT uptake, the addition of diazepam to patient warming significantly furthers the reduction in young patients, particularly female patients.
Original language | English |
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Pages (from-to) | 82-86 |
Number of pages | 5 |
Journal | Journal of Nuclear Medicine Technology |
Volume | 45 |
Issue number | 2 |
Early online date | 9 Mar 2017 |
DOIs | |
Publication status | Published - 1 Jun 2017 |
Externally published | Yes |
Keywords
- BAT
- brown fat
- 18 F-FDG PET
- diazepam