Pelvic irradiation and its effects on the lower urinary tract

a literature review

Cristiano Mendes Gomes*, Ricardo Vita Nunes, Vincent Tse

*Corresponding author for this work

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

The benefit of radiotherapy (RT) for pelvic tumors such as prostate and bladder cancer is well described. As cancer control rates improve, long-term survivorship issues become highly relevant to cancer management and it is essential to better understand the long-term effects of radiation. The risk and nature of radiation toxicity in a patient depend on treatment-related factors such as the total radiation dose, the dose per fraction, and schedule of treatment as well as patient-related factors like age, baseline lower urinary tract symptoms, previous surgery in an irradiated site, and co-morbidities. Radiation may also have a negative impact on the outcomes of surgical procedures for the treatment of lower urinary tract symptoms. Technical developments in radiation therapy such as intensity-modulated radiotherapy and the use of various forms of image-guided radiotherapy have enabled a decrease in the dose in organs surrounding the tumor that in many situations has reduced severe radiation-induced toxicities.

Original languageEnglish
Pages (from-to)295-302
Number of pages8
JournalCurrent Bladder Dysfunction Reports
Volume10
Issue number3
DOIs
Publication statusPublished - 1 Sep 2015
Externally publishedYes

Keywords

  • Bladder cancer
  • Hemorrhagic cystitis
  • Pelvic cancers
  • Prostate cancer
  • Radiation adverse effects
  • Radiotherapy
  • Urethral strictures

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