Peptide histidine valine

Its haemodynamic actions and pharmacokinetics in man differ from those of vasoactive intestinal peptide and peptide histidine methionine

J. S. Gill*, Y. Yiangou, D. J. Webb, L. Meleagros, N. Benjamin, B. J. Chrysanthou, J. R. Cockcroft, R. C. Causon, A. J. Camm, S. R. Bloom

*Corresponding author for this work

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The effects of intravenous and intra-arterial infusion of the peptides derived from prepro-vasoactive intestinal peptide, vasoactive intestinal peptide, peptide histidine methionine and peptide histidine valine, were examined in six healthy volunteers. Vasoactive intestinal peptide given intravenously caused a significant increase in heart rate and a decrease in diastolic, but not systolic, blood pressure, whereas peptide histidine valine caused an increase in heart rate alone, despite higher achieved circulating peptide concentrations. Peptide histidine methionine did not affect heart rate or blood pressure. Forearm blood flow was increased by vasoactive intestinal peptide and peptide histidine valine when infused locally intra-arterially, although vasoactive intestinal peptide was more potent than peptide histidine valine. Plasma concentrations of cardiodilatin (the N-terminal peptide derived from pro-atrial natriuretic peptide) were increased by intravenous infusion of vasoactive intestinal peptide, but were unaffected by peptide histidine methionine or peptide histidine valine. Circulating plasma concentrations of adrenaline and noradrenaline did not change during infusin of vasoactive intestinal peptide, peptide histidine methionine or peptide histidine valine.

Original languageEnglish
Pages (from-to)487-492
Number of pages6
JournalClinical Science
Volume78
Issue number5
Publication statusPublished - 1990
Externally publishedYes

Keywords

  • cardiovascular system
  • peptides

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    Gill, J. S., Yiangou, Y., Webb, D. J., Meleagros, L., Benjamin, N., Chrysanthou, B. J., ... Bloom, S. R. (1990). Peptide histidine valine: Its haemodynamic actions and pharmacokinetics in man differ from those of vasoactive intestinal peptide and peptide histidine methionine. Clinical Science, 78(5), 487-492.