Projects per year
Abstract
Trans‐blood‐brain barrier (BBB) delivery of therapeutic and diagnostic agents is a major challenge in the development of central nervous system (CNS) targeted radiopharmaceuticals. This review is an introduction to the use of peptides as delivery agents to transport cargos into the CNS. The most widely used BBB penetrating peptides are reviewed here, with a particular emphasis on the broad range of cargos delivered into the CNS using these. Cell penetrating peptides (CPPs) have been deployed as trans‐BBB delivery agents for some time; new developments in the CPP field offer exciting opportunities for the design of next generation trans‐BBB complexes. Many of the peptides highlighted here are ready to be combined with diagnostic and therapeutic radiopharmaceuticals to develop highly effective CNS targeted agents.
| Original language | English |
|---|---|
| Pages (from-to) | 237-248 |
| Number of pages | 12 |
| Journal | Journal of Labelled Compounds and Radiopharmaceuticals |
| Volume | 66 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Jul 2023 |
Bibliographical note
Copyright the Author(s) 2023. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.Keywords
- blood–brain barrier
- cell penetrating peptides,
- peptides
- radiopharmaceutical
- radiopharmaceuticals
- cell penetrating peptides
Fingerprint
Dive into the research topics of 'Peptides for trans‐blood brain barrier delivery'. Together they form a unique fingerprint.Projects
- 1 Finished
-
Single-session Introduction of Mutations in Parallel Lines (SIMPL)
1/01/21 → 31/12/23
Project: Research