Percutaneous atrial appendage occlusion for stroke prevention in patients with atrial fibrillation

A systematic review

Stine Munkholm-Larsen, Christopher Cao, Tristan D. Yan*, Steen Pehrson, Ulrik Dixen

*Corresponding author for this work

Research output: Contribution to journalReview article

21 Citations (Scopus)

Abstract

This review aims to evaluate systematically the safety and efficacy of percutaneous left atrial appendage occlusion (PLAAO) in stroke prevention for patients with atrial fibrillation (AF). A systematic review of peer-reviewed journals on PLAAO before June 2011 was performed on three electronic databases. Fourteen studies were identified for evaluation. Overall, implantation was successful in 93% of all cases. Periprocedural mortality and stroke rates were 1.1% and 0.6%, respectively. The incidences of pericardial effusion/cardiac tamponade and device embolisation were 4% and 0.7%, respectively. At the time of the latest follow-up (up to 40 months), the overall incidence of stroke among all studies was 1.4% per annum. Existing evidence suggests that PLAAO is a relatively safe treatment for patients with AF. However, there is a need for further evaluation of its efficacy in the form of large and well-designed randomised controlled trials.

Original languageEnglish
Pages (from-to)900-907
Number of pages8
JournalHeart
Volume98
Issue number12
DOIs
Publication statusPublished - Jun 2012
Externally publishedYes

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