Percutaneous radiofrequency ablation of pulmonary metastases from colorectal carcinoma

Prognostic determinants for survival

Tristan D. Yan*, Julie King, Adrian Sjarif, Derek Glenn, Karin Steinke, David L. Morris

*Corresponding author for this work

Research output: Contribution to journalArticle

118 Citations (Scopus)

Abstract

Background: Preliminary results have shown that percutaneous radiofrequency ablation (RFA) may play a useful role in patients with inoperable lung tumors. This series evaluated the prognostic features for survival in nonsurgical candidates who underwent percutaneous RFA of pulmonary metastases from colorectal carcinoma. Methods: Fifty-five patients not suitable for surgery underwent percutaneous RFA for colorectal pulmonary metastases. All clinical and treatment-related data were collected prospectively. The primary end point of the study was overall survival, defined from the time of RFA intervention. Univariate and multivariate analyses were performed to identify statistically significant prognostic parameters for overall survival. Results: The overall median survival was 33 months (range, 4-40 months), with actuarial 1-, 2-, and 3-year survival of 85%, 64%, and 46%, respectively. Univariate analysis demonstrated that largest size of lung metastasis (P < .001), location of lung metastases (P = .032), and repeat percutaneous RFA for pulmonary recurrence (P = .024) were statistically significant for overall survival. Multivariate analysis demonstrated that largest size of lung metastasis >3 cm was independently associated with a reduced overall survival (P = .003). Conclusions: Percutaneous lung RFA may play a useful role in nonsurgical candidates with colorectal pulmonary metastases. However, the survival benefit of this interventional procedure for patients with a pulmonary metastasis >3 cm was limited.

Original languageEnglish
Pages (from-to)1529-1537
Number of pages9
JournalAnnals of Surgical Oncology
Volume13
Issue number11
DOIs
Publication statusPublished - Nov 2006
Externally publishedYes

Keywords

  • Colorectal carcinoma
  • Pulmonary metastases
  • Radiofrequency ablation

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