Peripheral neuropathy phenotyping in rat models of type 2 diabetes mellitus: evaluating uptake of the neurodiab guidelines and identifying future directions

Md Jakir Hossain, Michael D. Kendig, Meg E. Letton, Margaret J. Morris, Ria Arnold*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)
1 Downloads (Pure)

Abstract

Diabetic peripheral neuropathy (DPN) affects over half of type 2 diabetes mellitus (T2DM) patients, with an urgent need for effective pharmacotherapies. While many rat and mouse models of T2DM exist, the phenotyping of DPN has been challenging with inconsistencies across laboratories. To better characterize DPN in rodents, a consensus guideline was published in 2014 to accelerate the translation of preclinical findings. Here we review DPN phenotyping in rat models of T2DM against the ‘Neurodiab’ criteria to identify uptake of the guidelines and discuss how DPN phenotypes differ between models and according to diabetes duration and sex. A search of PubMed, Scopus and Web of Science databases identified 125 studies, categorised as either diet and/or chemically induced models or transgenic/spontaneous models of T2DM. The use of diet and chemically induced T2DM models has exceeded that of transgenic models in recent years, and the introduction of the Neurodiab guidelines has not appreciably increased the number of studies assessing all key DPN endpoints. Combined high-fat diet and low dose streptozotocin rat models are the most frequently used and well characterised. Overall, we recommend adherence to Neurodiab guidelines for creating better animal models of DPN to accelerate translation and drug development.
Original languageEnglish
Pages (from-to)198-221
Number of pages24
JournalDiabetes and Metabolism Journal
Volume46
Issue number2
Early online date24 Mar 2022
DOIs
Publication statusPublished - Mar 2022
Externally publishedYes

Bibliographical note

Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • Diabetes mellitus
  • type 2
  • Diabetic neuropathies
  • Diet
  • high-fat
  • Models
  • animal
  • genetic
  • Peripheral nerves
  • Diabetes mellitus, type 2
  • Models, animal
  • Rats
  • Diet, high-fat
  • Models, genetic
  • Streptozotocin

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