Personalized lesion profiling in multiple sclerosis

Sidong Liu, Alexander Klistorner, Chenyu Wang, Yang Gao, Brittany Gilchrist, Yang Song, Yuyi You, Junen Yao, Weidong Cai, Michael Barnett

Research output: Contribution to conferencePaperpeer-review


The pathology of multiple sclerosis (MS) lesions is highly subject-specific, therefore personalized lesion analysis is important in assessing the degree of disease-related brain damage and the patient’s response to therapy. Separating and comparing lesional and non-lesional tissue provides an “internal control” and, therefore, increased precision of measurement of the degree of lesional damage in the brain. Here we present a novel and fully automatic method to create a personalized lesion profile of the subject based on DTI tractography, which can be used to assess
whole brain lesional damage. This technique can be applied to measure microstructural change using any MRI modality, and may have high translational impact in clinical trials and neurological research.
Original languageEnglish
Number of pages2
Publication statusPublished - Jun 2018
EventJoint Annual Meeting ISMRM-ESMRMB, 16-21 June 2018, Paris, France - Paris, France
Duration: 16 Jun 201821 Jun 2018


ConferenceJoint Annual Meeting ISMRM-ESMRMB, 16-21 June 2018, Paris, France


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