Personalized lesion profiling in multiple sclerosis

Sidong Liu, Alexander Klistorner, Chenyu Wang, Yang Gao, Brittany Gilchrist, Yang Song, Yuyi You, Junen Yao, Weidong Cai, Michael Barnett

Research output: Contribution to conferencePaperResearchpeer-review

Abstract

The pathology of multiple sclerosis (MS) lesions is highly subject-specific, therefore personalized lesion analysis is important in assessing the degree of disease-related brain damage and the patient’s response to therapy. Separating and comparing lesional and non-lesional tissue provides an “internal control” and, therefore, increased precision of measurement of the degree of lesional damage in the brain. Here we present a novel and fully automatic method to create a personalized lesion profile of the subject based on DTI tractography, which can be used to assess
whole brain lesional damage. This technique can be applied to measure microstructural change using any MRI modality, and may have high translational impact in clinical trials and neurological research.

Conference

ConferenceJoint Annual Meeting ISMRM-ESMRMB, 16-21 June 2018, Paris, France
CountryFrance
CityParis
Period16/06/1821/06/18

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Multiple Sclerosis
Brain
Brain Diseases
Clinical Trials
Pathology
Research
Therapeutics

Cite this

Liu, S., Klistorner, A., Wang, C., Gao, Y., Gilchrist, B., Song, Y., ... Barnett, M. (2018). Personalized lesion profiling in multiple sclerosis. Paper presented at Joint Annual Meeting ISMRM-ESMRMB, 16-21 June 2018, Paris, France, Paris, France.
Liu, Sidong ; Klistorner, Alexander ; Wang, Chenyu ; Gao, Yang ; Gilchrist, Brittany ; Song, Yang ; You, Yuyi ; Yao, Junen ; Cai, Weidong ; Barnett, Michael. / Personalized lesion profiling in multiple sclerosis. Paper presented at Joint Annual Meeting ISMRM-ESMRMB, 16-21 June 2018, Paris, France, Paris, France.2 p.
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title = "Personalized lesion profiling in multiple sclerosis",
abstract = "The pathology of multiple sclerosis (MS) lesions is highly subject-specific, therefore personalized lesion analysis is important in assessing the degree of disease-related brain damage and the patient’s response to therapy. Separating and comparing lesional and non-lesional tissue provides an “internal control” and, therefore, increased precision of measurement of the degree of lesional damage in the brain. Here we present a novel and fully automatic method to create a personalized lesion profile of the subject based on DTI tractography, which can be used to assesswhole brain lesional damage. This technique can be applied to measure microstructural change using any MRI modality, and may have high translational impact in clinical trials and neurological research.",
author = "Sidong Liu and Alexander Klistorner and Chenyu Wang and Yang Gao and Brittany Gilchrist and Yang Song and Yuyi You and Junen Yao and Weidong Cai and Michael Barnett",
year = "2018",
month = "6",
language = "English",
note = "Joint Annual Meeting ISMRM-ESMRMB, 16-21 June 2018, Paris, France ; Conference date: 16-06-2018 Through 21-06-2018",

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Liu, S, Klistorner, A, Wang, C, Gao, Y, Gilchrist, B, Song, Y, You, Y, Yao, J, Cai, W & Barnett, M 2018, 'Personalized lesion profiling in multiple sclerosis' Paper presented at Joint Annual Meeting ISMRM-ESMRMB, 16-21 June 2018, Paris, France, Paris, France, 16/06/18 - 21/06/18, .

Personalized lesion profiling in multiple sclerosis. / Liu, Sidong; Klistorner, Alexander; Wang, Chenyu; Gao, Yang; Gilchrist, Brittany; Song, Yang; You, Yuyi; Yao, Junen; Cai, Weidong; Barnett, Michael.

2018. Paper presented at Joint Annual Meeting ISMRM-ESMRMB, 16-21 June 2018, Paris, France, Paris, France.

Research output: Contribution to conferencePaperResearchpeer-review

TY - CONF

T1 - Personalized lesion profiling in multiple sclerosis

AU - Liu, Sidong

AU - Klistorner, Alexander

AU - Wang, Chenyu

AU - Gao, Yang

AU - Gilchrist, Brittany

AU - Song, Yang

AU - You, Yuyi

AU - Yao, Junen

AU - Cai, Weidong

AU - Barnett, Michael

PY - 2018/6

Y1 - 2018/6

N2 - The pathology of multiple sclerosis (MS) lesions is highly subject-specific, therefore personalized lesion analysis is important in assessing the degree of disease-related brain damage and the patient’s response to therapy. Separating and comparing lesional and non-lesional tissue provides an “internal control” and, therefore, increased precision of measurement of the degree of lesional damage in the brain. Here we present a novel and fully automatic method to create a personalized lesion profile of the subject based on DTI tractography, which can be used to assesswhole brain lesional damage. This technique can be applied to measure microstructural change using any MRI modality, and may have high translational impact in clinical trials and neurological research.

AB - The pathology of multiple sclerosis (MS) lesions is highly subject-specific, therefore personalized lesion analysis is important in assessing the degree of disease-related brain damage and the patient’s response to therapy. Separating and comparing lesional and non-lesional tissue provides an “internal control” and, therefore, increased precision of measurement of the degree of lesional damage in the brain. Here we present a novel and fully automatic method to create a personalized lesion profile of the subject based on DTI tractography, which can be used to assesswhole brain lesional damage. This technique can be applied to measure microstructural change using any MRI modality, and may have high translational impact in clinical trials and neurological research.

M3 - Paper

ER -

Liu S, Klistorner A, Wang C, Gao Y, Gilchrist B, Song Y et al. Personalized lesion profiling in multiple sclerosis. 2018. Paper presented at Joint Annual Meeting ISMRM-ESMRMB, 16-21 June 2018, Paris, France, Paris, France.