Pestalactams A-C

novel caprolactams from the endophytic fungus Pestalotiopsis sp.

Rohan A. Davis, Anthony R. Carroll, Katherine T. Andrews, Glen M. Boyle, Truc Linh Tran, Peter C. Healy, John A. Kalaitzis, Roger G. Shivas

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Chemical investigations of a fermentation culture from the endophytic fungus Pestalotiopsis sp. yielded three novel caprolactams, pestalactams A-C (1-3). The structures of 1-3 were determined by analysis of 1D and 2D-NMR, UV, IR, and MS data. The structure of pestalactam A was confirmed following single crystal X-ray diffraction analysis. Pestalactams A-C are the first C-7 alkylated caprolactam natural products to be reported. Pestalactams A (1) and B (2) were tested against two different strains of the malaria parasite Plasmodium falciparum (3D7 and Dd2), and the mammalian cell lines, MCF-7 and NFF, and showed modest in vitro activity in all assays.

Original languageEnglish
Pages (from-to)1785-1790
Number of pages6
JournalOrganic and Biomolecular Chemistry
Volume8
Issue number8
DOIs
Publication statusPublished - 21 Apr 2010
Externally publishedYes

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