Pharmacogenomics in general practice: the time has come

Thomas M. Polasek, Kym Mina, Graeme Suthers

    Research output: Contribution to journalArticlepeer-review

    8 Citations (Scopus)


    Background: Patients respond to medications differently because of variations in the genes that determine medication exposure and medication response. Objective: The aim of this review is to introduce pharmacogenomic testing and explain how to start using pharmacogenomic tests in general practice. Discussion: Knowledge of the variants in pharmacogenomics is useful when prescribing a variety of medications. International guidelines have identified at least 15 genes for which testing can inform the prescribing of 30 different medications with good evidence of clinical benefit. Nonetheless, pharmacogenomic tests should not be used as the sole basis for prescribing decisions, and should be considered in the context of other relevant clinical and laboratory features. General practitioners can incorporate pharmacogenomic tests into their clinical practice for patients with medication-related problems or those who are likely to require medications for which pharmacogenomics can provide guidance.

    Original languageEnglish
    Pages (from-to)100-105
    Number of pages6
    JournalAustralian Journal of General Practice
    Issue number3
    Publication statusPublished - 1 Mar 2019


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