TY - JOUR
T1 - Pharmacokinetic considerations for digoxin in older people
AU - Currie, Geoffrey M.
AU - Wheat, Janelle M.
AU - Kiat, Hosen
PY - 2011
Y1 - 2011
N2 - Objective: This review aims to arm readers with a deep understanding of pharmacokinetics of digoxin. Data Sources: Pharmacology and pharmacokinetic references texts, and peer reviewed medical journal manuscripts indexed on Medline included based on currency, accuracy and appropriateness. Results: Physiologic changes and disease associated with aging have an impact on pharmacokinetics and pharmacodynamics of medications. Altered drug response and increased adverse reactions are common amongst the elderly. The narrow therapeutic index of digoxin and pharmacokinetic changes associated with aging increases the risk of toxicity. In the aging population, a number of factors combine to increase the risk, severity and likelihood of hospitalisation or death due to adverse drug effects: • changes to absorption, distribution, metabolism and excretion, • increased susceptibility to drug sensitivity, • co-existing pathology, • polypharmacy. Conclusion: A thorough understanding of digoxin pharmacokinetics in the older person is essential for improved therapeutic outcomes, improved compliance, reduced morbidity and improved quality of life.
AB - Objective: This review aims to arm readers with a deep understanding of pharmacokinetics of digoxin. Data Sources: Pharmacology and pharmacokinetic references texts, and peer reviewed medical journal manuscripts indexed on Medline included based on currency, accuracy and appropriateness. Results: Physiologic changes and disease associated with aging have an impact on pharmacokinetics and pharmacodynamics of medications. Altered drug response and increased adverse reactions are common amongst the elderly. The narrow therapeutic index of digoxin and pharmacokinetic changes associated with aging increases the risk of toxicity. In the aging population, a number of factors combine to increase the risk, severity and likelihood of hospitalisation or death due to adverse drug effects: • changes to absorption, distribution, metabolism and excretion, • increased susceptibility to drug sensitivity, • co-existing pathology, • polypharmacy. Conclusion: A thorough understanding of digoxin pharmacokinetics in the older person is essential for improved therapeutic outcomes, improved compliance, reduced morbidity and improved quality of life.
KW - ageing
KW - digoxin
KW - pharmacokinetics
KW - toxicity
UR - http://www.scopus.com/inward/record.url?scp=80053479046&partnerID=8YFLogxK
U2 - 10.2174/1874192401105010130
DO - 10.2174/1874192401105010130
M3 - Review article
C2 - 21769303
AN - SCOPUS:80053479046
VL - 5
SP - 130
EP - 135
JO - Open Cardiovascular Medicine Journal
JF - Open Cardiovascular Medicine Journal
SN - 1874-1924
ER -