Phonological and articulatory impairment in Alzheimer's disease: A case series

Karen Croot, John R. Hodges*, John Xuereb, Karalyn Patterson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

80 Citations (Scopus)


We demonstrate that phonological and articulatory impairments may occur at presentation or early in the course of Alzheimer's disease, contrary to claims that these aspects of language production are relatively preserved until the final stages of this disease. Six patients with pathologically confirmed Alzheimer's disease (AD) and four patients with clinically diagnosed dementia of the Alzheimer's type (DAT) presented with one of five different clinical profiles: Nonfluent progressive aphasia, mixed progressive aphasia, progressive aphasia diagnosed as DAT from neuropsychological assessment, initial amnestic syndrome with prominent phonological errors, and biparietal syndrome. Analysis of their conversational speech, single-word production, and performance of highly familiar series speech tasks such as counting revealed false start errors, phonological paraphasias, and/or articulatory difficulty. Neuropathological changes were located in left perisylvian regions consistent with speech and language impairment but atypical for Alzheimer's disease. (C) 2000 Academic Press.

Original languageEnglish
Pages (from-to)277-309
Number of pages33
JournalBrain and Language
Issue number2
Publication statusPublished - 2000
Externally publishedYes


  • Alzheimer's disease
  • Articulation
  • Dementia
  • Language
  • Phonology
  • Progressive aphasia


Dive into the research topics of 'Phonological and articulatory impairment in Alzheimer's disease: A case series'. Together they form a unique fingerprint.

Cite this