Phosphoglycosylation: A new structural class of glycosylation?

Paul A. Haynes*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

57 Citations (Scopus)


There are a number of different glycoproteins that have been identified relatively recently which contain oligosaccharides linked to serine or threonine in a peptide backbone via phosphodiesters. It is possible that these glycoproteins may form an alternative structural class of glycosylation. This modification has been referred to as phosphoglycosylation (Mehta et al., 1996; J. Biol. Chem., 271, 10897-10903), and has been reported in slime molds and several unicellular parasites. In this review, examples of phosphoglycosylation from different biological sources are discussed. Those which are well characterized have been found to be highly variable with respect to the glycan moiety, while sharing some common features. An experimental approach detailing how to determine whether a protein is phosphoglycosylated is also presented.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
Issue number1
Publication statusPublished - Jan 1998
Externally publishedYes


  • Glycoprotein
  • Glycosylation
  • Phosphodiester
  • Phosphoglycosylation


Dive into the research topics of 'Phosphoglycosylation: A new structural class of glycosylation?'. Together they form a unique fingerprint.

Cite this