Phylogeny of multidrug transporters

Milton H. Saier; Ian T. Paulsen

doi:10.1006/scdb.2000.0246

Phylogeny of multidrug transporters

Milton H. Saier^*, Ian T. Paulsen

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

297 Citations (Scopus)

Abstract

We currently recognize five large ubiquitous superfamilies and one small eukaryotic-specific family in which cellular multidrug efflux pumps occur. One, the ABC superfamily, includes members that use ATP hydrolysis to drive drug efflux, but the MFS, RND, MATE and DMT superfamilies include members that are secondary carriers, functioning by drug:H⁺ or drug:Na⁺ antiport mechanisms. The small MET family seems to be restricted to endosomal membranes of eukaryotes, and only a single such system has been functionally characterized. In this review article, these families of drug transporters are discussed and evaluated from phylogenetic standpoints.

Original language	English
Pages (from-to)	205-213
Number of pages	9
Journal	Seminars in Cell and Developmental Biology
Volume	12
Issue number	3
DOIs	https://doi.org/10.1006/scdb.2000.0246
Publication status	Published - 2001
Externally published	Yes

Keywords

Drugs
Evolution
Phylogeny
Transporters

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10.1006/scdb.2000.0246

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AB - We currently recognize five large ubiquitous superfamilies and one small eukaryotic-specific family in which cellular multidrug efflux pumps occur. One, the ABC superfamily, includes members that use ATP hydrolysis to drive drug efflux, but the MFS, RND, MATE and DMT superfamilies include members that are secondary carriers, functioning by drug:H+ or drug:Na+ antiport mechanisms. The small MET family seems to be restricted to endosomal membranes of eukaryotes, and only a single such system has been functionally characterized. In this review article, these families of drug transporters are discussed and evaluated from phylogenetic standpoints.

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KW - Evolution

KW - Phylogeny

KW - Transporters

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Phylogeny of multidrug transporters

Abstract

Keywords

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