Physical activity and brain amyloid beta: a longitudinal analysis of cognitively unimpaired older adults

Michael G. Slee; Stephanie R. Rainey-Smith; Victor L. Villemagne; James D. Doecke; Hamid R. Sohrabi; Kevin Taddei; David Ames; Vincent Dore; Paul Maruff; Simon M. Laws; Colin L. Masters; Christopher C. Rowe; Ralph N. Martins; Kirk I. Erickson; Belinda M. Brown

doi:10.1002/alz.13556

Physical activity and brain amyloid beta: a longitudinal analysis of cognitively unimpaired older adults

Michael G. Slee^*, Stephanie R. Rainey-Smith, Victor L. Villemagne, James D. Doecke, Hamid R. Sohrabi, Kevin Taddei, David Ames, Vincent Dore, Paul Maruff, Simon M. Laws, Colin L. Masters, Christopher C. Rowe, Ralph N. Martins, Kirk I. Erickson, Belinda M. Brown

^*Corresponding author for this work

Macquarie Medical School

Research output: Contribution to journal › Article › peer-review

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Abstract

INTRODUCTION: The current study evaluated the relationship between habitual physical activity (PA) levels and brain amyloid beta (Aβ) over 15 years in a cohort of cognitively unimpaired older adults. METHODS: PA and Aβ measures were collected over multiple timepoints from 731 cognitively unimpaired older adults participating in the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study of Aging. Regression modeling examined cross-sectional and longitudinal relationships between PA and brain Aβ. Moderation analyses examined apolipoprotein E (APOE) ε4 carriage impact on the PA-Aβ relationship. RESULTS: PA was not associated with brain Aβ at baseline (β = –0.001, p = 0.72) or over time (β = –0.26, p = 0.24). APOE ε4 status did not moderate the PA-Aβ relationship over time (β = 0.12, p = 0.73). Brain Aβ levels did not predict PA trajectory (β = –54.26, p = 0.59). DISCUSSION: Our study did not identify a relationship between habitual PA and brain Aβ levels. Highlights: Physical activity levels did not predict brain amyloid beta (Aβ) levels over time in cognitively unimpaired older adults (≥60 years of age). Apolipoprotein E (APOE) ε4 carrier status did not moderate the physical activity–brain Aβ relationship over time. Physical activity trajectories were not impacted by brain Aβ levels.

Original language	English
Pages (from-to)	1350-1359
Number of pages	10
Journal	Alzheimer's and Dementia
Volume	20
Issue number	2
Early online date	20 Nov 2023
DOIs	https://doi.org/10.1002/alz.13556
Publication status	Published - Feb 2024

Bibliographical note

Copyright the Author(s) 2023. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

Alzheimer's disease
amyloid beta
dementia
exercise
genetics
longitudinal
physical activity

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10.1002/alz.13556Licence: CC BY-NC

Publisher version (open access)Final published version, 680 KBLicence: CC BY-NC

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Slee, M. G., Rainey-Smith, S. R., Villemagne, V. L., Doecke, J. D., Sohrabi, H. R., Taddei, K., Ames, D., Dore, V., Maruff, P., Laws, S. M., Masters, C. L., Rowe, C. C., Martins, R. N., Erickson, K. I., & Brown, B. M. (2024). Physical activity and brain amyloid beta: a longitudinal analysis of cognitively unimpaired older adults. Alzheimer's and Dementia, 20(2), 1350-1359. https://doi.org/10.1002/alz.13556

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title = "Physical activity and brain amyloid beta: a longitudinal analysis of cognitively unimpaired older adults",

abstract = "INTRODUCTION: The current study evaluated the relationship between habitual physical activity (PA) levels and brain amyloid beta (Aβ) over 15 years in a cohort of cognitively unimpaired older adults. METHODS: PA and Aβ measures were collected over multiple timepoints from 731 cognitively unimpaired older adults participating in the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study of Aging. Regression modeling examined cross-sectional and longitudinal relationships between PA and brain Aβ. Moderation analyses examined apolipoprotein E (APOE) ε4 carriage impact on the PA-Aβ relationship. RESULTS: PA was not associated with brain Aβ at baseline (β = –0.001, p = 0.72) or over time (β = –0.26, p = 0.24). APOE ε4 status did not moderate the PA-Aβ relationship over time (β = 0.12, p = 0.73). Brain Aβ levels did not predict PA trajectory (β = –54.26, p = 0.59). DISCUSSION: Our study did not identify a relationship between habitual PA and brain Aβ levels. Highlights: Physical activity levels did not predict brain amyloid beta (Aβ) levels over time in cognitively unimpaired older adults (≥60 years of age). Apolipoprotein E (APOE) ε4 carrier status did not moderate the physical activity–brain Aβ relationship over time. Physical activity trajectories were not impacted by brain Aβ levels.",

keywords = "Alzheimer's disease, amyloid beta, dementia, exercise, genetics, longitudinal, physical activity",

author = "Slee, {Michael G.} and Rainey-Smith, {Stephanie R.} and Villemagne, {Victor L.} and Doecke, {James D.} and Sohrabi, {Hamid R.} and Kevin Taddei and David Ames and Vincent Dore and Paul Maruff and Laws, {Simon M.} and Masters, {Colin L.} and Rowe, {Christopher C.} and Martins, {Ralph N.} and Erickson, {Kirk I.} and Brown, {Belinda M.}",

note = "Copyright the Author(s) 2023. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.",

year = "2024",

month = feb,

doi = "10.1002/alz.13556",

language = "English",

volume = "20",

pages = "1350--1359",

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Slee, MG, Rainey-Smith, SR, Villemagne, VL, Doecke, JD, Sohrabi, HR, Taddei, K, Ames, D, Dore, V, Maruff, P, Laws, SM, Masters, CL, Rowe, CC, Martins, RN, Erickson, KI & Brown, BM 2024, 'Physical activity and brain amyloid beta: a longitudinal analysis of cognitively unimpaired older adults', Alzheimer's and Dementia, vol. 20, no. 2, pp. 1350-1359. https://doi.org/10.1002/alz.13556

TY - JOUR

T1 - Physical activity and brain amyloid beta

T2 - a longitudinal analysis of cognitively unimpaired older adults

AU - Slee, Michael G.

AU - Rainey-Smith, Stephanie R.

AU - Villemagne, Victor L.

AU - Doecke, James D.

AU - Sohrabi, Hamid R.

AU - Taddei, Kevin

AU - Ames, David

AU - Dore, Vincent

AU - Maruff, Paul

AU - Laws, Simon M.

AU - Masters, Colin L.

AU - Rowe, Christopher C.

AU - Martins, Ralph N.

AU - Erickson, Kirk I.

AU - Brown, Belinda M.

N1 - Copyright the Author(s) 2023. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2024/2

Y1 - 2024/2

N2 - INTRODUCTION: The current study evaluated the relationship between habitual physical activity (PA) levels and brain amyloid beta (Aβ) over 15 years in a cohort of cognitively unimpaired older adults. METHODS: PA and Aβ measures were collected over multiple timepoints from 731 cognitively unimpaired older adults participating in the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study of Aging. Regression modeling examined cross-sectional and longitudinal relationships between PA and brain Aβ. Moderation analyses examined apolipoprotein E (APOE) ε4 carriage impact on the PA-Aβ relationship. RESULTS: PA was not associated with brain Aβ at baseline (β = –0.001, p = 0.72) or over time (β = –0.26, p = 0.24). APOE ε4 status did not moderate the PA-Aβ relationship over time (β = 0.12, p = 0.73). Brain Aβ levels did not predict PA trajectory (β = –54.26, p = 0.59). DISCUSSION: Our study did not identify a relationship between habitual PA and brain Aβ levels. Highlights: Physical activity levels did not predict brain amyloid beta (Aβ) levels over time in cognitively unimpaired older adults (≥60 years of age). Apolipoprotein E (APOE) ε4 carrier status did not moderate the physical activity–brain Aβ relationship over time. Physical activity trajectories were not impacted by brain Aβ levels.

AB - INTRODUCTION: The current study evaluated the relationship between habitual physical activity (PA) levels and brain amyloid beta (Aβ) over 15 years in a cohort of cognitively unimpaired older adults. METHODS: PA and Aβ measures were collected over multiple timepoints from 731 cognitively unimpaired older adults participating in the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study of Aging. Regression modeling examined cross-sectional and longitudinal relationships between PA and brain Aβ. Moderation analyses examined apolipoprotein E (APOE) ε4 carriage impact on the PA-Aβ relationship. RESULTS: PA was not associated with brain Aβ at baseline (β = –0.001, p = 0.72) or over time (β = –0.26, p = 0.24). APOE ε4 status did not moderate the PA-Aβ relationship over time (β = 0.12, p = 0.73). Brain Aβ levels did not predict PA trajectory (β = –54.26, p = 0.59). DISCUSSION: Our study did not identify a relationship between habitual PA and brain Aβ levels. Highlights: Physical activity levels did not predict brain amyloid beta (Aβ) levels over time in cognitively unimpaired older adults (≥60 years of age). Apolipoprotein E (APOE) ε4 carrier status did not moderate the physical activity–brain Aβ relationship over time. Physical activity trajectories were not impacted by brain Aβ levels.

KW - Alzheimer's disease

KW - amyloid beta

KW - dementia

KW - exercise

KW - genetics

KW - longitudinal

KW - physical activity

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DO - 10.1002/alz.13556

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AN - SCOPUS:85177220934

SN - 1552-5260

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SP - 1350

EP - 1359

JO - Alzheimer's and Dementia

JF - Alzheimer's and Dementia

IS - 2

ER -

Physical activity and brain amyloid beta: a longitudinal analysis of cognitively unimpaired older adults

Abstract

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