Physical activity is associated with macular thickness: a multi-cohort observational study

Ella C. Berry; Henry N. Marshall; Sean Mullany; Santiago Diaz Torres; Joshua Schmidt; Daniel Thomson; Lachlan S. W. Knight; Georgina L. Hollitt; Ayub Qassim; Bronwyn Ridge; Angela Schulz; Mark M. Hassall; Thi Thi Nguyen; Stewart Lake; Richard A. Mills; Ashish Agar; Anna Galanopoulos; John Landers; Paul R. Healey; Stuart L. Graham; Alex W. Hewitt; Stuart MacGregor; Robert J. Casson; Owen M. Siggs; Jamie E. Craig

doi:10.1167/iovs.64.3.11

Physical activity is associated with macular thickness: a multi-cohort observational study

Ella C. Berry, Henry N. Marshall, Sean Mullany, Santiago Diaz Torres, Joshua Schmidt, Daniel Thomson, Lachlan S. W. Knight, Georgina L. Hollitt, Ayub Qassim, Bronwyn Ridge, Angela Schulz, Mark M. Hassall, Thi Thi Nguyen, Stewart Lake, Richard A. Mills, Ashish Agar, Anna Galanopoulos, John Landers, Paul R. Healey, Stuart L. GrahamAlex W. Hewitt, Stuart MacGregor, Robert J. Casson, Owen M. Siggs, Jamie E. Craig

Macquarie Medical School

Research output: Contribution to journal › Article › peer-review

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Abstract

Purpose: To assess the association between physical activity and spectral-domain optical coherence tomography (SD-OCT)-measured rates of macular thinning in an adult population with primary open-angle glaucoma. Methods: The correlation between accelerometer-measured physical activity and rates of macular ganglion cell-inner plexiform layer (GCIPL) thinning was measured in 735 eyes from 388 participants of the Progression Risk of Glaucoma: RElevant SNPs with Significant Association (PROGRESSA) study. The association between accelerometer-measured physical activity and cross-sectional SD-OCT macular thickness was then assessed in 8862 eyes from 6152 participants available for analysis in the UK Biobank who had SD-OCT, ophthalmic, comorbidity, and demographic data. Results: Greater physical activity was associated with slower rates of macular GCIPL thinning in the PROGRESSA study (beta = 0.07 µm/y/SD; 95% confidence interval [CI], 0.03-0.13; P = 0.003) after adjustment for ophthalmic, demographic and systemic predictors of macular thinning. This association persisted in subanalyses of participants characterized as glaucoma suspects (beta = 0.09 µm/y/SD; 95% CI, 0.03-0.15; P = 0.005). Participants in the upper tertile (greater than 10,524 steps/d) exhibited a 0.22-µm/y slower rate of macular GCIPL thinning than participants in the lower tertile (fewer than 6925 steps/d): -0.40 ± 0.46 µm/y versus -0.62 ± 0.55 µm/y (P = 0.003). Both time spent doing moderate/vigorous activity and mean daily active calories were positively correlated with rate of macular GCIPL thinning (moderate/vigorous activity: beta = 0.06 µm/y/SD; 95% CI, 0.01-0.105; P = 0.018; active calories: beta = 0.06 µm/y/SD; 95% CI, 0.006-0.114; P = 0.032). Analysis among 8862 eyes from the UK Biobank revealed a positive association between physical activity and cross-sectional total macular thickness (beta = 0.8 µm/SD; 95% CI, 0.47-1.14; P < 0.001). Conclusions: These results highlight the potential neuroprotective benefits of exercise on the human retina.

Original language	English
Article number	11
Pages (from-to)	1-8
Number of pages	8
Journal	Investigative Ophthalmology and Visual Science
Volume	64
Issue number	3
DOIs	https://doi.org/10.1167/iovs.64.3.11
Publication status	Published - 1 Mar 2023

Bibliographical note

Copyright the Author(s) 2023. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

macular
physical activity
optical coherence tomography
aging
exercise

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Berry, E. C., Marshall, H. N., Mullany, S., Torres, S. D., Schmidt, J., Thomson, D., Knight, L. S. W., Hollitt, G. L., Qassim, A., Ridge, B., Schulz, A., Hassall, M. M., Nguyen, T. T., Lake, S., Mills, R. A., Agar, A., Galanopoulos, A., Landers, J., Healey, P. R., ... Craig, J. E. (2023). Physical activity is associated with macular thickness: a multi-cohort observational study. Investigative Ophthalmology and Visual Science, 64(3), 1-8. Article 11. https://doi.org/10.1167/iovs.64.3.11

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title = "Physical activity is associated with macular thickness: a multi-cohort observational study",

abstract = "Purpose: To assess the association between physical activity and spectral-domain optical coherence tomography (SD-OCT)-measured rates of macular thinning in an adult population with primary open-angle glaucoma. Methods: The correlation between accelerometer-measured physical activity and rates of macular ganglion cell-inner plexiform layer (GCIPL) thinning was measured in 735 eyes from 388 participants of the Progression Risk of Glaucoma: RElevant SNPs with Significant Association (PROGRESSA) study. The association between accelerometer-measured physical activity and cross-sectional SD-OCT macular thickness was then assessed in 8862 eyes from 6152 participants available for analysis in the UK Biobank who had SD-OCT, ophthalmic, comorbidity, and demographic data. Results: Greater physical activity was associated with slower rates of macular GCIPL thinning in the PROGRESSA study (beta = 0.07 µm/y/SD; 95% confidence interval [CI], 0.03-0.13; P = 0.003) after adjustment for ophthalmic, demographic and systemic predictors of macular thinning. This association persisted in subanalyses of participants characterized as glaucoma suspects (beta = 0.09 µm/y/SD; 95% CI, 0.03-0.15; P = 0.005). Participants in the upper tertile (greater than 10,524 steps/d) exhibited a 0.22-µm/y slower rate of macular GCIPL thinning than participants in the lower tertile (fewer than 6925 steps/d): -0.40 ± 0.46 µm/y versus -0.62 ± 0.55 µm/y (P = 0.003). Both time spent doing moderate/vigorous activity and mean daily active calories were positively correlated with rate of macular GCIPL thinning (moderate/vigorous activity: beta = 0.06 µm/y/SD; 95% CI, 0.01-0.105; P = 0.018; active calories: beta = 0.06 µm/y/SD; 95% CI, 0.006-0.114; P = 0.032). Analysis among 8862 eyes from the UK Biobank revealed a positive association between physical activity and cross-sectional total macular thickness (beta = 0.8 µm/SD; 95% CI, 0.47-1.14; P < 0.001). Conclusions: These results highlight the potential neuroprotective benefits of exercise on the human retina.",

keywords = "macular, physical activity, optical coherence tomography, aging, exercise",

author = "Berry, {Ella C.} and Marshall, {Henry N.} and Sean Mullany and Torres, {Santiago Diaz} and Joshua Schmidt and Daniel Thomson and Knight, {Lachlan S. W.} and Hollitt, {Georgina L.} and Ayub Qassim and Bronwyn Ridge and Angela Schulz and Hassall, {Mark M.} and Nguyen, {Thi Thi} and Stewart Lake and Mills, {Richard A.} and Ashish Agar and Anna Galanopoulos and John Landers and Healey, {Paul R.} and Graham, {Stuart L.} and Hewitt, {Alex W.} and Stuart MacGregor and Casson, {Robert J.} and Siggs, {Owen M.} and Craig, {Jamie E.}",

note = "Copyright the Author(s) 2023. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.",

year = "2023",

month = mar,

day = "1",

doi = "10.1167/iovs.64.3.11",

language = "English",

volume = "64",

pages = "1--8",

journal = "Investigative Ophthalmology and Visual Science",

issn = "1552-5783",

publisher = "Association for Research in Vision and Ophthalmology",

number = "3",

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Berry, EC, Marshall, HN, Mullany, S, Torres, SD, Schmidt, J, Thomson, D, Knight, LSW, Hollitt, GL, Qassim, A, Ridge, B, Schulz, A, Hassall, MM, Nguyen, TT, Lake, S, Mills, RA, Agar, A, Galanopoulos, A, Landers, J, Healey, PR, Graham, SL, Hewitt, AW, MacGregor, S, Casson, RJ, Siggs, OM & Craig, JE 2023, 'Physical activity is associated with macular thickness: a multi-cohort observational study', Investigative Ophthalmology and Visual Science, vol. 64, no. 3, 11, pp. 1-8. https://doi.org/10.1167/iovs.64.3.11

TY - JOUR

T1 - Physical activity is associated with macular thickness

T2 - a multi-cohort observational study

AU - Berry, Ella C.

AU - Marshall, Henry N.

AU - Mullany, Sean

AU - Torres, Santiago Diaz

AU - Schmidt, Joshua

AU - Thomson, Daniel

AU - Knight, Lachlan S. W.

AU - Hollitt, Georgina L.

AU - Qassim, Ayub

AU - Ridge, Bronwyn

AU - Schulz, Angela

AU - Hassall, Mark M.

AU - Nguyen, Thi Thi

AU - Lake, Stewart

AU - Mills, Richard A.

AU - Agar, Ashish

AU - Galanopoulos, Anna

AU - Landers, John

AU - Healey, Paul R.

AU - Graham, Stuart L.

AU - Hewitt, Alex W.

AU - MacGregor, Stuart

AU - Casson, Robert J.

AU - Siggs, Owen M.

AU - Craig, Jamie E.

N1 - Copyright the Author(s) 2023. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2023/3/1

Y1 - 2023/3/1

N2 - Purpose: To assess the association between physical activity and spectral-domain optical coherence tomography (SD-OCT)-measured rates of macular thinning in an adult population with primary open-angle glaucoma. Methods: The correlation between accelerometer-measured physical activity and rates of macular ganglion cell-inner plexiform layer (GCIPL) thinning was measured in 735 eyes from 388 participants of the Progression Risk of Glaucoma: RElevant SNPs with Significant Association (PROGRESSA) study. The association between accelerometer-measured physical activity and cross-sectional SD-OCT macular thickness was then assessed in 8862 eyes from 6152 participants available for analysis in the UK Biobank who had SD-OCT, ophthalmic, comorbidity, and demographic data. Results: Greater physical activity was associated with slower rates of macular GCIPL thinning in the PROGRESSA study (beta = 0.07 µm/y/SD; 95% confidence interval [CI], 0.03-0.13; P = 0.003) after adjustment for ophthalmic, demographic and systemic predictors of macular thinning. This association persisted in subanalyses of participants characterized as glaucoma suspects (beta = 0.09 µm/y/SD; 95% CI, 0.03-0.15; P = 0.005). Participants in the upper tertile (greater than 10,524 steps/d) exhibited a 0.22-µm/y slower rate of macular GCIPL thinning than participants in the lower tertile (fewer than 6925 steps/d): -0.40 ± 0.46 µm/y versus -0.62 ± 0.55 µm/y (P = 0.003). Both time spent doing moderate/vigorous activity and mean daily active calories were positively correlated with rate of macular GCIPL thinning (moderate/vigorous activity: beta = 0.06 µm/y/SD; 95% CI, 0.01-0.105; P = 0.018; active calories: beta = 0.06 µm/y/SD; 95% CI, 0.006-0.114; P = 0.032). Analysis among 8862 eyes from the UK Biobank revealed a positive association between physical activity and cross-sectional total macular thickness (beta = 0.8 µm/SD; 95% CI, 0.47-1.14; P < 0.001). Conclusions: These results highlight the potential neuroprotective benefits of exercise on the human retina.

AB - Purpose: To assess the association between physical activity and spectral-domain optical coherence tomography (SD-OCT)-measured rates of macular thinning in an adult population with primary open-angle glaucoma. Methods: The correlation between accelerometer-measured physical activity and rates of macular ganglion cell-inner plexiform layer (GCIPL) thinning was measured in 735 eyes from 388 participants of the Progression Risk of Glaucoma: RElevant SNPs with Significant Association (PROGRESSA) study. The association between accelerometer-measured physical activity and cross-sectional SD-OCT macular thickness was then assessed in 8862 eyes from 6152 participants available for analysis in the UK Biobank who had SD-OCT, ophthalmic, comorbidity, and demographic data. Results: Greater physical activity was associated with slower rates of macular GCIPL thinning in the PROGRESSA study (beta = 0.07 µm/y/SD; 95% confidence interval [CI], 0.03-0.13; P = 0.003) after adjustment for ophthalmic, demographic and systemic predictors of macular thinning. This association persisted in subanalyses of participants characterized as glaucoma suspects (beta = 0.09 µm/y/SD; 95% CI, 0.03-0.15; P = 0.005). Participants in the upper tertile (greater than 10,524 steps/d) exhibited a 0.22-µm/y slower rate of macular GCIPL thinning than participants in the lower tertile (fewer than 6925 steps/d): -0.40 ± 0.46 µm/y versus -0.62 ± 0.55 µm/y (P = 0.003). Both time spent doing moderate/vigorous activity and mean daily active calories were positively correlated with rate of macular GCIPL thinning (moderate/vigorous activity: beta = 0.06 µm/y/SD; 95% CI, 0.01-0.105; P = 0.018; active calories: beta = 0.06 µm/y/SD; 95% CI, 0.006-0.114; P = 0.032). Analysis among 8862 eyes from the UK Biobank revealed a positive association between physical activity and cross-sectional total macular thickness (beta = 0.8 µm/SD; 95% CI, 0.47-1.14; P < 0.001). Conclusions: These results highlight the potential neuroprotective benefits of exercise on the human retina.

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Physical activity is associated with macular thickness: a multi-cohort observational study

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